AI Article Synopsis
- Single-cell gene expression studies in mammalian tissues reveal important stage-specific molecular processes that are crucial for understanding different cell types and their developmental pathways.
- The authors propose the creation of a Pediatric Cell Atlas to be integrated into the Human Cell Atlas consortium, which will create detailed single-cell profiles of gene expression in human tissues and organs.
- This Pediatric Cell Atlas will enhance existing research on adults and development, offering valuable insights into pediatric health issues and the genetic and environmental factors affecting health throughout one's lifetime.
Article Abstract
Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616346 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2019.03.001 | DOI Listing |
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