Two new compounds Talaromycin A () and Talaromycin B () were isolated from a liquid culture of The structures of and were elucidated by IR, MS, 1D and 2D NMR spectra and comparison of the experimental and calculated electronic circular dichroism spectra. Additional known compounds () were also isolated. These compounds were tested for monoamine oxidase, acetylcholinesterase and PI3K inhibitory activity, but showed only weak activity.
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http://dx.doi.org/10.1080/14786419.2019.1593163 | DOI Listing |
Nat Prod Res
October 2020
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou , PR China.
Chem Biodivers
November 2018
School of Life Science, Jiangsu Normal University, Xuzhou, 221116, P. R. China.
The active metabolites investigation of Talaromyces sp. (strain No. MH551540) associated with Xanthoparmelia angustiphylla afforded one new δ-lactone, talaromycin A (1), together with six known compounds, clearanol A (2), 6-methylbiphenyl-3,3',4,5'-tetraol (3), desmethylaltenusin (4), ergone (5), ergosterol (6), and palmitic acid (7).
View Article and Find Full Text PDFChem Biodivers
March 2015
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China, (phone/fax: +86-532-82031536).
Three new diphenyl ether derivatives, talaromycins A-C (1-3, resp.), together with six known analogs, 4-9, were isolated from a gorgonian-derived fungus, Talaromyces sp. The structures of the new compounds were determined by analysis of extensive NMR spectroscopic data.
View Article and Find Full Text PDFChemistry
October 2000
Institut für Organische Chemie, Georg-August-Universität Göttingen, Germany.
Hetero-Diels-Alder reaction of the steroidal exocyclic enol ethers 14 and 15, obtained from the secoestrones 8 and 9 by reduction, iodoetherification, and elimination, with ethyl O-benzoyldiformylacetate (16) leads to the spiroacetals 17 and 18 as a mixture of four diastereomers. Reduction of the major diastereomers 17a and 18a with DIBAH and subsequent hydrogenation yields the novel natural product hybrids 21, 23, 24, and 25, which possess the structural features of the steroid estrone (7) and the mycotoxin talaromycin 6.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
October 1998
Institut für Organische Chemie der Universität, Tammannstrasse 2, D-37077 Göttingen (Germany), Fax: (+49) 551-399476.
Numerous pharmacologically interesting compounds are available by the synthesis of hybrid natural products. Thus, for instance, the estrone-talaromycin hybrid 2, which is synthesized in a few steps from the estrone derivative 1 by a sequence in which a hetero-Diels-Alder reaction is the key step, exhibits notable cytotoxic activity.
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