Background: Biomarkers may be a sensitive measure of disease activity in patients with multiple sclerosis (pwMS).
Objective: A pwMS had a marked increase of neurofilament light chain (NfL) in CSF 9-weeks prior to a clinical exacerbation.
Methods And Results: Brain MRI, CSF, EDSS were measured at baseline, 6 weeks and 28 weeks. The patient had an exacerbation at week 15 of study but the NfL measured at week 6 were found to show a nearly 3-fold increase of CSF NfL levels prior to symptoms when the NfL levels were later measured.
Conclusion: This is an example supporting the usefulness of NfL in monitoring disease activity in pwMS which may predict disease activity prior to a clinical exacerbation.
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| http://dx.doi.org/10.1016/j.msard.2019.03.016 | DOI Listing |
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