Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neulet.2019.03.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1.
Front Oral Health
December 2024
School of Stomatology, Southwest Medical University, Lu Zhou, China.
Introduction: Tissue repair can be promoted by moderate inflammation but suppressed by excessive levels. Therefore, control of excessive inflammation following removal of infection plays a critical role in promotion of pulpal repair. Connexin 43 (Cx43) forms hemichannels (HCs) or gap channels (GJs) to facilitate the delivery of small molecules between cells to regulate both inflammation and repair.
View Article and Find Full Text PDFExpression of Wnt signaling proteins in rare congenital bladder disorders.
J Pediatr Urol
October 2024
Centre for Gene Therapy and Regenerative Medicine, Guy's Hospital, Great Maze Pond, King's College London, London SE1 9RT, UK; Department of Cell and Developmental Biology, Rockefeller Building, University Street, University College London, London WC1E 6JJ, UK. Electronic address:
Introduction And Aims: Congenital bladder anomalies are rare and are a leading cause of end stage renal failure in children. The Wnt signaling pathway, important during embryonic development, has been implicated in the pathogenesis of these conditions through regulation of gene expression, including essential transcription factors. We investigated the expression of four Wnt transcriptional targets, namely, Pygopus 1 (Pygo1), Connexin 43 (Cx43), FRA1 and TCF7L1 in three rare congenital bladder disorders: bladder exstrophy (BE), neurogenic bladder (NGB) and posterior urethral valves (PUV).
View Article and Find Full Text PDFClinical Impact of Connexin 43 Deregulation on Myocardial Infraction.
Maedica (Bucur)
June 2024
Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: Coronary artery disease (CAD) is a major and multifaceted health problem but also the first cause of death in modern Western societies. Furthermore, myocardial infarction (MI) constitutes a challenge for analysis in the field of molecular mechanisms, early diagnosis and therapeutic approaches, as its incidence increases every year worldwide. Concerning the histopathological diagnosis in the corresponding cases, a variety of immunohistochemistry (IHC) markers and methods are available to support conventional histology diagnosis.
View Article and Find Full Text PDFExtracellular matrix substrates differentially influence enteric glial cell homeostasis and immune reactivity.
Front Immunol
August 2024
Department of Surgery, Medical Faculty, University Hospital Bonn, Bonn, Germany.
Article Synopsis
- Enteric glial cells play a crucial role in gut functions like motility and inflammation, and they change their behavior during inflammation, making them important for understanding gut health.
- The study investigates how different extracellular matrix (ECM) coatings affect the purity, structure, and immune response of cultured enteric glial cells using microscopy and gene sequencing techniques.
- Results show that Matrigel and laminin provide the best growth conditions for enteric glial cells, promoting intercellular communication and influencing gene expression differently compared to other ECMs when activated by inflammation.
Introduction Cirrhotic cardiomyopathy (CCM) is recognized by impaired cardiac responsiveness to stress, prolonged QT interval, and systolic and diastolic dysfunctions. Connexins are a family of transmembrane proteins that play a key role in cardiac physiology. Connexin 43 (Cx43) inhibition showed cardio-protective effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!