AI Article Synopsis
- Severe Fever with Thrombocytopenia Syndrome (SFTS) is a serious viral disease that can be confused with Hemorrhagic Fever with Renal Syndrome (HFRS) due to similar symptoms and transmission patterns.
- A study analyzing serum samples from 128 patients diagnosed with HFRS found that 4 of them actually had SFTS, indicating these patients were misdiagnosed and faced the risk of receiving inappropriate treatment.
- Misdiagnosing SFTS as HFRS is concerning because it can lead to increased mortality rates and higher chances of spreading the virus among others, emphasizing the need for accurate diagnosis and isolation protocols for SFTS patients.
Article Abstract
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever with a high fatality rate and high frequency of person-to-person transmission and is caused by SFTSV, a tick-borne Phlebovirus. Because SFTS has similar clinical manifestations and epidemic characters (such as spatial and temporal distributions) with hemorrhagic fever with renal syndrome (HFRS) in China, we reason that SFTS patients might be misdiagnosed as HFRS.
Methodology/principal Findings: Acute-phase sera of 128 clinically diagnosed HFRS patients were retrospectively analyzed for Hantavirus IgM antibodies with ELISA. Hantavirus-negative patients' sera were further analyzed for SFTSV IgM antibodies with ELISA. ELISA showed that 73 of 128 (57.0%) of clinically diagnosed HFRS patients were IgM antibody positive to Hantaviruses. Among the 55 Hantavirus-IgM negative patients, four (7.3%) were IgM antibody positive to SFTSV. The results indicated that the four SFTS patients were misdiagnosed as HFRS. The misdiagnosed SFTS patients had clinical manifestations common to HFRS and were unable to be differentiated from HFRS clinically.
Conclusions: Our study showed that SFTS patients could be clinically misdiagnosed as HFRS. The misdiagnosis of SFTS as HFRS causes particular concern because it may increase the risk of death of SFTS patients and person-to-person transmission of SFTSV without proper care for and isolation of SFTS patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457554 | PMC |
| http://dx.doi.org/10.1371/journal.pntd.0007308 | DOI Listing |
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