AI Article Synopsis
- The study aimed to explore how androgen deprivation therapy (ADT) affects depression and cognitive functions in men with advanced prostate cancer.
- It involved 144 patients, comparing those on ADT for 12 months to a control group that had undergone surgery; results revealed significant cognitive declines and higher depression scores in the ADT group.
- Findings suggest that ADT increases depression and impairs cognitive abilities like language and memory, highlighting the need for careful consideration before prescribing ADT to older patients with other health issues.
Article Abstract
Aim: To investigate association of androgen deprivation therapy (ADT) with depression and the effect of depression on cognitive functions in men with locally advanced or metastatic prostate cancer.
Methods: A total of 144 patients were evaluated in a prospective, comparative study. Group1 consisted of 72 patients with locally advanced or metastatic prostate cancer who received complete ADT treatment continuously for 12 months and group2 (control group) consisted of 72 patients who underwent radical prostatectomy without any additional treatment. MoCA (The Montreal Cognitive Assessment) and HAM-D (Hamilton depression rating scale) tests were used to assess the effects of ADT on depression and cognitive functions.
Results: According to post-treatment results of MoCA test, patients had lower mean total scores in both the groups. The deficits were especially prominent in the areas of language ability and short-term memory capacity. In the comparison of two groups according to HAM-D tests, the scores were significantly higher in group1 at baseline-6 month, at baseline-12 month and at 6-12 month follow-up period ( = .003, < .001, = .023).There was a relationship between depression and deterioration of language and memory functions at 6th ( < .001, = .002) and 12th months ( < .001, = .046). Attention function was deteriorated in these patients at 6th ( < .001) and 12th months ( < .001).
Conclusions: ADT causes increase in depression and the deterioration of cognitive functions. ADT should be given carefully to these older group of patients with concomitant morbidities.
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| http://dx.doi.org/10.1080/13685538.2019.1586869 | DOI Listing |
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