AI Article Synopsis
- Therapeutic plasma exchange (TPE) is a medical treatment used mostly for autoimmune diseases, which happen when the body's immune system attacks itself.
- TPE works by removing harmful substances from the blood, like bad antibodies and other immune stuff, to help the body heal.
- Medical experts have created guidelines to explain when and how to use TPE for different types of diseases, especially when regular treatments aren’t working.
Article Abstract
Therapeutic plasma exchange (TPE) has been mainly used in the treatment of autoimmune diseases. The main mechanisms of action of TPE include the removal of circulating autoantibodies, immune complexes, complement components, cytokines and adhesion molecules, along with sensitization of antibody-producing cells to immunosuppressant agents. TPE is useful in autoimmune haematological, renal, rheumatic and neurological diseases, and is recommended for acute disorders, together with relapsed or worsened chronic diseases that are often unresponsive to conventional treatments. The American Society for Apheresis and the British Society of Haematology have published guidelines on the clinical use of apheresis procedures, indicating the different levels of efficacy of TPE. Based on the evidence from current literature and our personal experience, this review discusses the indications and the suggested regimens for TPE in autoimmune haematological and non-haematological disorders.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/bjh.15903 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!