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Clinical relevance of macromolecular complexes involving integrins, potassium and sodium ion channels and the sodium/proton antiporter in human breast cancer.
Cancer Cell Int
January 2025
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Background: Mounting evidence underline the relevance of macromolecular complexes in cancer. Integrins frequently recruit ion channels and transporters within complexes which behave as signaling hubs. A complex composed by β1 integrin, hERG1 K channel, the neonatal form of the Na channel Na 1.
View Article and Find Full Text PDFLayered Double Hydroxide Nanosheets Incorporated Hierarchical Hydrogen Bonding Polymer Networks for Transparent and Fire-Proof Ceramizable Coatings.
Nanomicro Lett
January 2025
Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen, 361000, People's Republic of China.
In recent decades, annual urban fire incidents, including those involving ancient wooden buildings burned, transportation, and solar panels, have increased, leading to significant loss of human life and property. Addressing this issue without altering the surface morphology or interfering with optical behavior of flammable materials poses a substantial challenge. Herein, we present a transparent, low thickness, ceramifiable nanosystem coating composed of a highly adhesive base (poly(SSS-co-HEMA)), nanoscale layered double hydroxide sheets as ceramic precursors, and supramolecular melamine di-borate as an accelerator.
View Article and Find Full Text PDFMechano-gated iontronic piezomemristor for temporal-tactile neuromorphic plasticity.
Nat Commun
January 2025
School of Future Technology, University of Chinese Academy of Sciences, 100190, Beijing, PR China.
In bioneuronal systems, the synergistic interaction between mechanosensitive piezo channels and neuronal synapses can convert and transmit pressure signals into complex temporal plastic pulses with excitatory and inhibitory features. However, existing artificial tactile neuromorphic systems struggle to replicate the elaborate temporal plasticity observed between excitatory and inhibitory features in biological systems, which is critical for the biomimetic processing and memorizing of tactile information. Here we demonstrate a mechano-gated iontronic piezomemristor with programmable temporal-tactile plasticity.
View Article and Find Full Text PDFTreatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the international space station, and after 120 days recovery on Earth.
Life Sci Space Res (Amst)
February 2025
Department of Radiation Oncology, Wake Forest University School of Medicine. Winston-Salem, NC, USA. Electronic address:
Reduced weight-bearing during spaceflight has been associated with musculoskeletal degradation that risks astronaut health and performance in transit and upon reaching deep space destinations. Previous rodent experiments aboard the international space station (ISS) have identified that the spaceflight-induced molecular arthritic phenotype was characterized with an increase in oxidative stress. This study evaluated if treatment with a superoxide dismutase (SOD) mimetic on orbit could prevent spaceflight-induced damage to the knee and hip articular cartilage, and the menisci in rodents.
View Article and Find Full Text PDFSpace biological and human survival: Investigations into plants, animals, microorganisms and their components and bioregenerative life support systems.
Life Sci Space Res (Amst)
February 2025
Holosensor Medical Technology Ltd, Room 12, No. 1798, Zhonghuayuan West Road, Yushan Town, Suzhou 215000, PR China; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. Electronic address:
Space life science has been a frontier discipline in the life sciences, aiming to study the life phenomena of earth organisms and their activity patterns under the special environment of space. This review summarizes studies in various key topics in space life science, namely, how microbiome changes in humans and plants, the development of space agriculture and the use of animal, plant and cell models to study the effect of space environments on physiology. We highlight the new possibilities of using high-quality protein crystals uniquely available when grown under space conditions to aid drug development on earth, and the state-of-the-art Bioregenerative Life Support Systems (BLSS) to achieve long term human survival in space.
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