AI Article Synopsis
- A novel fluorescent sensor called CPM has been developed to specifically detect calcium (Ca) and fluoride (F) ions, showing strong fluorescence when interacting with Ca compared to other metal ions.
- The CPM-Ca complex can selectively identify fluoride amongst various anions, boasting detection limits of 5.81 × 10^-6 M for Ca and 4.28 × 10^-6 M for F in a buffered aqueous solution.
- Various methods such as UV-vis titration and fluorescence imaging confirm that CPM is capable of penetrating cells, allowing for effective detection of Ca and F within living cells.
Article Abstract
A novel fluorescent sensor CPM for relay detecting Ca and F based on coumarin has conveniently synthesized and characterized. The sensor CPM showed highly fluorescence enhancement to Ca over other metal ions, and the CPM-Ca complex could selectively recognize F among other anions. The limits of detection for Ca and F were 5.81 × 10 M and 4.28 × 10 M in aqueous solution (DMF/HEPES buffer 1:1 v/v, 10 mM, pH = 7.2), respectively. Their sensing mode had been testified by Job's plots, UV-vis titration, H NMR titrations, ESI-mass, fluorescence and DFT calculations. The fluorescence imaging indicated that CPM was cell-permeable and could be used to effectively detect Ca and F within living cells.
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| http://dx.doi.org/10.1016/j.saa.2019.03.035 | DOI Listing |
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