Emerging technologies in organ preservation, tissue engineering and regenerative medicine: a blessing or curse for transplantation?

Transpl Int

Vascularized Composite Allotransplantation (VCA) Laboratory, Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Published: July 2019

AI Article Synopsis

  • Advances in transplant medicine since the 1950s have greatly improved surgical techniques and immunosuppressive therapies, leading to successful organ transplants.
  • The growing gap between organ supply and demand poses a significant challenge, limiting the ability to save and improve lives through transplantation.
  • Emerging technologies in regenerative medicine and tissue engineering aim to increase organ availability and create new organ sources, offering hope for overcoming current limitations in transplantation.

Article Abstract

Since the beginning of transplant medicine in the 1950s, advances in surgical technique and immunosuppressive therapy have created the success story of modern organ transplantation. However, today more than ever, we are facing a huge discrepancy between organ supply and demand, limiting the potential for transplantation to save and improve the lives of millions. To address the current limitations and shortcomings, a variety of emerging new technologies focusing on either maximizing the availability of organs or on generating new organs and organ sources hold great potential to eventully overcoming these hurdles. These advances are mainly in the field of regenerative medicine and tissue engineering. This review gives an overview of this emerging field and its multiple sub-disciplines and highlights recent advances and existing limitations for widespread clinical application and potential impact on the future of transplantation.

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Source
http://dx.doi.org/10.1111/tri.13432DOI Listing

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