Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00005721-198609000-00004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy.
Pharmaceuticals (Basel)
December 2024
Dipartimento di Scienze della Vita, della Salute e delle Professioni Sanitarie, Università degli Studi "Link Campus University", Via del Casale di S. Pio V 44, I-00165 Rome, Italy.
, , and parasites are responsible for infectious diseases threatening millions of people worldwide. Despite more recent efforts devoted to the search for new antiprotozoal agents, efficacy, safety, and resistance issues still hinder the development of suited therapeutic options. The lack of robustly validated targets and the complexity of parasite's diseases have made phenotypic screening a preferential drug discovery strategy for the identification of new chemical entities.
View Article and Find Full Text PDFArtificial Intelligence In Health And Health Care: Priorities For Action.
Health Aff (Millwood)
January 2025
Eric Horvitz, Microsoft, Redmond, Washington.
The field of artificial intelligence (AI) has entered a new cycle of intense opportunity, fueled by advances in deep learning, including generative AI. Applications of recent advances affect many aspects of everyday life, yet nowhere is it more important to use this technology safely, effectively, and equitably than in health and health care. Here, as part of the National Academy of Medicine's Vital Directions for Health and Health Care: Priorities for 2025 initiative, which is designed to provide guidance on pressing health care issues for the incoming presidential administration, we describe the steps needed to achieve these goals.
View Article and Find Full Text PDFMalpractice or masterful practice? Navigating vicarious liability in healthcare.
World J Clin Cases
January 2025
Department of Orthopaedics, Government Medical College, Omandurar Government Estate, Chennai 600002, Tamil Nadu, India.
In the intricate landscape of healthcare, vicarious liability looms large, shaping the responsibilities and actions of healthcare practitioners and administrators alike. Illustrated by a poignant scenario of a medication error, this article navigates the complexities of vicarious liability in healthcare. It explains the legal basis and ramifications of this theory, emphasizing its importance in fostering responsibility, protecting patient welfare, and easing access to justice.
View Article and Find Full Text PDFModular Maximization Theory: A functional account of economic behavior in laboratory animal models with applications to drug-seeking behavior.
Neurosci Biobehav Rev
January 2025
Arizona State University, United States.
Substance abuse research depends on precise and sensitive assessments of reinforcer efficacy in animal models. However, conventional methods often lack theoretical rigor and specificity to support these assessments. To address these gaps, the Modular Maximization Theory (MMT) is introduced as a comprehensive framework for understanding instrumental behavior.
View Article and Find Full Text PDFEfficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction.
Proc Natl Acad Sci U S A
January 2025
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.
Dysregulation of GABAergic inhibition is associated with pathological pain. Consequently, enhancement of GABAergic transmission represents a potential analgesic strategy. However, therapeutic potential of current GABA agonists and modulators is limited by unwanted side effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!