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| http://dx.doi.org/10.18240/ijo.2019.03.26 | DOI Listing |
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Atrial Fibrillation and Retinal Stroke.
JAMA Netw Open
January 2025
Department of Neurology, Duke University School of Medicine, Durham, North Carolina.
Importance: Atrial fibrillation (AF) is the most common, chronic, cardiac arrythmia in older US adults. It is not known whether AF is independently associated with increased risk of retinal stroke (central retinal artery occlusion), a subtype of ischemic stroke that causes severely disabling visual loss in most cases and is a harbinger of further vascular events.
Objective: To determine whether there is an association between AF and retinal stroke.
Background: The retina, an integral part of the central nervous system, can exhibit protein accumulation (Aβ and pTau) associated with neurodegenerative diseases such as Alzheimer's disease (AD). Biochemical analysis revealed the existence of a distinct primary retinal tauopathy (PReT), differing from AD and primary age-related tauopathy (PART) brain lysates, suggesting it as a potential precursor for AD tauopathy with possible diagnostic value. However, it remains unclear whether retinal pTau pathology can spread from the eye into the brain.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Australian Alzheimer's Research Foundation, Perth, Western Australia, Australia.
Background: As an extension of the central nervous system (CNS), the retina shares many similarities with the brain and can manifest signs of various neurological diseases, including Alzheimer's disease (AD). This study investigates the spectral features of the retina to develop a classification model for the differentiation of individuals with elevated brain amyloid levels.
Method: Participants (n=66) with varying brain Aβ levels, as determined by brain imaging, were non-invasively imaged using a hyperspectral retinal camera at wavelengths of 450 to 905 nm.
Background: People with Down syndrome (pwDS) have a high prevalence of early-onset Alzheimer's disease (AD). With the two-fold increase in life expectancy for pwDS, identifying early biomarkers for AD in this patient population is needed (PMID: 32593336). Previously we have shown that phenotyping using ultra-widefield retinal imaging (UWFI) has the potential to identify peripheral retinal biomarkers for AD, such as higher prevalence of peripheral hard drusen (pHD) and lower peripheral retinal vascular fractal dimension (RVFD) compared to controls (Ctrl) (PMID: 29621759, PMID: 34458553).
View Article and Find Full Text PDFDry eye disease and morphological changes in the anterior chamber in people with cystic fibrosis.
J Cyst Fibros
January 2025
Pulmonology Department, Regional University Hospital of Malaga, Department of Medicine and Dermatology, University of Malaga, Biomedical Research Institute of Malaga (IBIMA) - Bionand Platform, Malaga, Spain. Electronic address:
Background: Cystic fibrosis (CF) is caused by variants in a gene that encodes a protein essential for water and ion transport in the epithelial cells of exocrine organs. Given the possible relationship of this protein and conjunctival and corneal epithelium, the aim of this study was to evaluate ophthalmologic alterations in people with CF.
Methods: Forty-five people with CF underwent pulmonary evaluation including inflammatory score (IS).
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