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The Drivers and Barriers of Clinical Health Professions Student Flourishing: An Integrative Review.
J Physician Assist Educ
January 2025
Stephanie Neary, PhD, MPA, PA-C, is an assistant professor adjunct and the director of Didactic Education in the Yale University Physician Assistant Online Program, New Haven, Connecticut. This review was conducted while a PhD in Nursing Science student at the Medical University of South Carolina, Charleston, South Carolina.
Introduction: To determine the drivers and barriers to flourishing for clinical health professions students through a review of peer-reviewed literature.
Methods: Articles were analyzed in Scopus, PubMed, and EBSCOHost and hand-searched education journals through May 2024 describing flourishing among clinical health professions students. Whittemore and Knafl's integrative approach was used, and quality was assessed by the Mixed Methods Appraisal Tool.
New Onset Diabetes in Pancreatic Adenocarcinoma Does Not Correlate With Molecular Subtype.
J Surg Oncol
December 2024
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Background And Objectives: Studies show that new onset diabetes mellitus (DM) (NOD) predates the diagnosis of PDAC by up to 2 years. Two tumor-intrinsic molecular subtypes of PDAC that are prognostic and predictive of chemotherapy response have been described and validated. We hypothesize that patients with NOD may have different molecular subtypes and prognoses.
View Article and Find Full Text PDFBig Data and Oral Health Disparities: A Critical Appraisal.
J Dent Res
December 2024
Oral Health Academic Programme, Duke-NUS Medical School, Singapore.
Big data has emerged as a pivotal asset in addressing oral health disparities in recent years. Big data encompasses the vast pool of health care-related biomedical information sourced from diverse channels, such as claims data, patient registries, and electronic health records (EHRs). This study is a critical review that synthesizes the evidence, identifies gaps in knowledge, and discusses future implications regarding big data analytics and oral health disparities.
View Article and Find Full Text PDFHigh tumor glucocorticoid receptor expression in early-stage, triple-negative breast cancer is associated with increased T-regulatory cell infiltration.
Breast Cancer Res Treat
November 2024
Section of Hematology and Oncology, Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.
Article Synopsis
- In early-stage triple-negative breast cancer (TNBC), high glucocorticoid receptor (GR) expression is linked to poor outcomes, potentially due to an immunosuppressed tumor microenvironment.
- A study of 47 patients showed that high GR expression correlated with increased levels of immunosuppressive FOXP3+ regulatory T cells and BATF3+ immune cells, but not significantly with CD8+ T cell infiltration.
- The findings suggest that high GR expression may contribute to a more immunosuppressed state in TNBC, which could explain worse prognoses for patients with GR-positive tumors.
Mobility-Based Smartphone Digital Phenotypes for Unobtrusively Capturing Everyday Cognition, Mood, and Community Life-Space in Older Adults: Feasibility, Acceptability, and Preliminary Validity Study.
JMIR Hum Factors
November 2024
Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, United States.
Background: Current methods of monitoring cognition in older adults are insufficient to address the growing burden of Alzheimer disease and related dementias (AD/ADRD). New approaches that are sensitive, scalable, objective, and reflective of meaningful functional outcomes are direly needed. Mobility trajectories and geospatial life space patterns reflect many aspects of cognitive and functional integrity and may be useful proxies of age-related cognitive decline.
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