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Bilateral Choroidal Metastases from Primary Cutaneous Melanoma Following Nivolumab Discontinuation: A Case Report.
Ocul Immunol Inflamm
January 2025
Ocular Oncology Service, Institute of Oncology, Tecnologico de Monterrey, Monterrey, Mexico.
Purpose: To present the case of a young patient with BRAF V600E-mutant cutaneous melanoma who developed bilateral choroidal metastases complicated by neovascular glaucoma (NVG) in both eyes following the interruption of nivolumab therapy.
Methods: A 28-year-old female with primary cutaneous melanoma of the left hand underwent surgical resection and adjuvant nivolumab. Immunotherapy was discontinued due to immune-related acute interstitial nephritis.
SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors.
Front Biosci (Landmark Ed)
January 2025
Division of Molecular Psychiatry, Center of Mental Health, University of Hospital Würzburg, 97080 Würzburg, Germany.
Background: The inheritance of the short allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions. Both central and peripheral mechanisms of the compromised serotonin (5-HT) system play crucial roles in this context. Previous studies on SERT-deficient (Sert) mice, which model human SERT deficiency, have demonstrated emotional and metabolic disturbances, exacerbated by exposure to a high-fat Western diet (WD).
View Article and Find Full Text PDFClinical Features of Human Parvovirus B19-Associated Encephalitis Identified in the Dakar Region, Senegal, and Viral Genome Characterization.
Viruses
January 2025
Virology Department, Institut Pasteur de Dakar, 36 Avenue Pasteur, Dakar 200, Senegal.
Neurological manifestations associated with human parvovirus B19 (B19V) infections are rare and varied. Acute encephalitis and encephalopathy are the most common, accounting for 38.8% of all neurological manifestations associated with human B19V.
View Article and Find Full Text PDFDiversity and Distribution of Species Along an Elevation Gradient in Natural and Semi-Natural Forest Ecosystems in Portugal.
Pathogens
January 2025
Centre for Environmental and Marine Studies (CESAM), Departamento de Biologia, Universidade de Aveiro, 3810-193 Aveiro, Portugal.
Globally, forests are constantly threatened by a plethora of disturbances of natural and anthropogenic origin, such as climate change, forest fires, urbanization, and pollution. Besides the most common stressors, during the last few years, Portuguese forests have been impacted by severe decline phenomena caused by invasive pathogens, many of which belong to the genus . The genus includes a large number of species that are invading forest ecosystems worldwide, chiefly as a consequence of global trade and human activities.
View Article and Find Full Text PDFThe Impact of Exercise Play on the Biomechanical Characteristics of Single-Leg Jumping in 5- to 6-Year-Old Preschool Children.
Sensors (Basel)
January 2025
College of P.E. and Sports, Beijing Normal University, Beijing 100875, China.
Objective: This study aimed to investigate the effects of a 12-week self-designed exercise game intervention on the kinematic and kinetic data of the supporting leg in preschool children during the single-leg jump.
Methods: Thirty 5- to 6-year-old preschool children were randomly divided into an experimental group (EG) and a control group (CG). The BTS SMART DX motion capture analysis system was used to collect single-leg jump data before the intervention.
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