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Asparagine endopeptidase regulates lysosome homeostasis via modulating endomembrane phosphoinositide composition.
Cell Death Dis
January 2025
College of Pharmacy, Dali University, Dali 671003, Yunnan, PR China.
Asparagine endopeptidase (AEP) is ubiquitously expressed in both physiological and pathological contexts, yet its precise role and functional mechanism in breast cancer remain elusive. Here, we identified increased AEP expression in breast cancer tissues, which correlated with poorer survival rates and a propensity for lung metastasis among breast cancer patients. Loss of AEP impaired colony formation by breast cancer cells in vitro and suppressed lung metastasis in mice.
View Article and Find Full Text PDFLegumain in cardiovascular diseases.
Exp Biol Med (Maywood)
August 2024
Department of Vascular Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, having become a global public health problem, so the pathophysiological mechanisms and therapeutic strategies of CVDs need further study. Legumain is a powerful enzyme that is widely distributed in mammals and plays an important role in a variety of biological processes. Recent research suggests that legumain is associated with the occurrence and progression of CVDs.
View Article and Find Full Text PDFCo-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis.
Sci Rep
April 2024
College of Pharmacy, Dali University, 2 HongShen Road, Dali, 671003, Yunnan, China.
Legumain (or asparagine endopeptidase/AEP) is a lysosomal cysteine endopeptidase associated with increased invasive and migratory behavior in a variety of cancers. In this study, co-delivery of Cas9 mRNA and guide RNA (gRNA) by lipid nanoparticles (LNP) for editing of LGMN gene was performed. For in-vitro transcription (IVT) of gRNA, two templates were designed: linearized pUC57-T7-gRNA and T7-gRNA oligos, and the effectiveness of gRNA was verified in multiple ways.
View Article and Find Full Text PDFThe Role of Cytokines and Molecular Pathways in Lung Fibrosis Following SARS-CoV-2 Infection: A Physiopathologic (Re)view.
Biomedicines
March 2024
Faculty of Medicine, University of Medicine and Pharmacy Carol Davila, No. 37, Dionisie Lupu Street, Sector 2, 020021 Bucharest, Romania.
SARS-CoV-2 infection is a significant health concern that needs to be addressed not only during the initial phase of infection but also after hospitalization. This is the consequence of the various pathologies associated with long COVID-19, which are still being studied and researched. Lung fibrosis is an important complication after COVID-19, found in up to 71% of patients after discharge.
View Article and Find Full Text PDFRNA-Seq transcriptomic landscape profiling of spontaneously hypertensive rats treated with a sodium-glucose cotransporter 2 (SGLT2) inhibitor.
Biomed Pharmacother
October 2023
Department of Nephrology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 4000l0, China. Electronic address:
Article Synopsis
- Sodium-glucose co-transporter-2 inhibitors (SGLT2i) like empagliflozin are effective in reducing cardiovascular disease and improving kidney health in diabetic patients, but their specific effects on hypertensive individuals need more research.
- This study used RNA sequencing to explore how empagliflozin affects gene expression in various tissues (like the kidney and lungs) in hypertensive rats, alongside blood pressure measurements to validate the findings.
- Results showed significant changes in gene expression linked to blood pressure and metabolism regulation, with evidence of reduced pro-inflammatory factors and increased anti-inflammatory markers after empagliflozin treatment.
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