AI Article Synopsis
- * Low-hypodiploid B-cell precursor ALL patients have a significantly higher 5-year cumulative incidence of relapse compared to high-hypodiploids (52% vs. 12%).
- * Younger low-hypodiploid BCP-ALL patients (≤35 years) demonstrate better survival rates and lower relapse than older patients, who generally face worse prognoses despite achieving good treatment responses.
Article Abstract
The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.
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| http://dx.doi.org/10.1111/bjh.15887 | DOI Listing |
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