Recent decades have seen intense developments of hydrogel applications for cell cultures, tissue engineering, soft robotics, and ionic devices. Advanced fabrication techniques for hydrogel structures are being developed to meet user-specified requirements. Existing hydrogel 3D printing techniques place substantial constraints on the physical and chemical properties of hydrogel precursors as well as the printed hydrogel structures. This study proposes a novel method for patterning liquids with a resolution of 100 μm by using the capacitor edge effect. We establish a complete hydrogel 3D printing system combining the patterning and stacking processes. This technique is applicable to a wide variety of hydrogels, overcoming the limitations of existing techniques. We demonstrate printed hydrogel structures including a hydrogel scaffold, a hydrogel composite that responds sensitively to temperature, and an ionic high-integrity hydrogel display device. The proposed technique offers great opportunities in rapid prototyping hydrogel devices using multiple compositions and complex geometries.
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http://dx.doi.org/10.1126/sciadv.aau8769 | DOI Listing |
Eur J Pharm Biopharm
January 2025
BASF SE, Carl-Bosch-Strasse 38, 67056 Ludwigshafen am Rhein, Germany. Electronic address:
Poloxamer 338 is used as versatile thermo-responsive gelling agent in topical and sub-cutaneous applications. Due to application specific needs a gel point below body or even below room temperature is required. The influence of inorganic salts and active pharmaceutical ingredients (APIs) on the gel point was investigated using oscillatory rheology to identify the driving forces and predictors for gel point alteration.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science & Technology, No. 29, 13th Avenue, Tianjin Economic and Technological Development Area, Tianjin 300457, China. Electronic address:
In this study, we innovatively prepared a multifunctional lignin crosslinked polyacrylamide (L-cPAM) hydrogel by a sequential two-step strategy of crosslinking of lignin and crosslinked polyacrylamide (cPAM) followed by the polymerization of cPAM. The hydrogen bonding and crosslinking between the molecular chains of lignin and PAM established a rigid and porous network structure, which provided the L-cPAM hydrogel with excellent mechanical strength, thermal stability, and salinity resistance. A series of lignin dosages (0 to 30 %) were investigated during the crosslinking of lignin and PAM.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Chemistry Department, Faculty of Science, Damietta University, Damietta 34517, Egypt. Electronic address:
The VCo-LDH/CS hydrogel beads were created by combining VCo-layered double hydroxide (VCo-LDH) and chitosan (CS) using a cross-linking process with epichlorohydrin. These beads were specifically designed to remove tetracycline (TTC). To characterize the VCo-LDH/CS hydrogel beads, several analytical techniques were used, with PXRD, XPS, FESEM, EDX, and FT-IR.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Microbiology, College of Life Science, Key Laboratory for Agriculture Microbiology, Shandong Agricultural University, Tai'an 271018, PR China; School of Pharmacy, the Key Laboratory of Medical Antibacterial Materials of Shandong Province, Binzhou Medical University, Yantai 264003, PR China. Electronic address:
Chronic wounds caused by microbial infection have emerged as a major challenge on patients and medical health system. Bacterial cellulose (BC) characterized by its excellent biocompatibility and porous network, holds promise for addressing complex wound issues. However, lack of inherent antibacterial activity and cross-linking sites in the molecular network of BC have constrained its efficacy in hydrogel design and treatment of bacterial-infected wounds.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
The Affiliated Lihuili Hospital of Ningbo University, Ningbo 315040, China.
Cartilage repair remains a formidable challenge because of its limited regenerative capacity. Construction of a biomimetic hydrogel matrix that can induce cell aggregation is a promising therapeutic option. Cell aggregates are more beneficial than dissociated cells for improving survival and chondrogenic differentiation, thereby facilitating cartilage repair.
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