AI Article Synopsis
- Sensing environmental cues relies on complex neuronal circuits connected to the body's surface, with sensory neurons forming dendrites that make skin the largest sensory organ.
- Past research indicates that the type and function of these neurons, along with how their dendrites branch, are influenced by internal factors.
- New studies, particularly in Drosophila and Caenorhabditis elegans, reveal how epidermal cells can impact the growth and health of sensory dendrites on their surfaces.
Article Abstract
Sensing environmental cues requires well-built neuronal circuits linked to the body surface. Sensory neurons generate dendrites to innervate surface epithelium, thereby making it the largest sensory organ in the body. Previous studies have illustrated that neuronal type, physiological function and branching patterns are determined by intrinsic factors. Perhaps for effective sensation or protection, sensory dendrites bind to or are surrounded by the substrate epidermis. Recent studies have shed light on the mechanisms by which dendrites interact with their substrates. These interactions suggest that substrates can regulate dendrite guidance, arborization and degeneration. In this review, we focus on recent studies of Drosophila and Caenorhabditis elegans that demonstrate how epidermal cells can regulate dendrites in several aspects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451362 | PMC |
| http://dx.doi.org/10.1098/rsob.180257 | DOI Listing |
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