The adult mammalian heart, unlike in some amphibian and fish species, is generally considered a post-mitotic organ. In this issue of Developmental Cell, Monroe et al. (2019) show that the expression of constitutively active YAP induces a remarkable degree of proliferation in preexisting adult cardiomyocytes by globally altering chromatin accessibility.
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| http://dx.doi.org/10.1016/j.devcel.2019.03.007 | DOI Listing |
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