Background Abdominal and thoracic CT provide a valuable opportunity for osteoporosis screening regardless of the clinical indication for imaging. Purpose To establish reference normative ranges for first lumbar vertebra (L1) trabecular attenuation values across all adult ages to measure bone mineral density (BMD) at routine CT. Materials and Methods Reference data were constructed from 20 374 abdominal and/or thoracic CT examinations performed at 120 kV. Data were derived from adults (mean age, 60 years ± 12 [standard deviation]; 56.1% [11 428 of 20 374] women). CT examinations were performed with ( = 4263) or without ( = 16 111) intravenous contrast agent administration for a variety of unrelated clinical indications between 2000 and 2018. L1 Hounsfield unit measurement was obtained either with a customized automated tool ( = 11 270) or manually by individual readers ( = 9104). The effects of patient age, sex, contrast agent, and manual region-of-interest versus fully automated L1 Hounsfield unit measurement were assessed using multivariable logistic regression analysis. Results Mean L1 attenuation decreased linearly with age at a rate of 2.5 HU per year, averaging 226 HU ± 44 for patients younger than 30 years and 89 HU ± 38 for patients 90 years or older. Women had a higher mean L1 attenuation compared with men ( < .008) until menopause, after which both groups had similar values. Administration of intravenous contrast agent resulted in negligible differences in mean L1 attenuation values except in patients younger than 40 years. The fully automated method resulted in measurements that were average 21 HU higher compared with manual measurement ( < .004); at intrapatient subanalysis, this difference was related to the level of transverse measurement used (midvertebra vs off-midline level). Conclusion Normative ranges of L1 vertebra trabecular attenuation were established across all adult ages, and these can serve as a quick reference at routine CT to identify adults with low bone mineral density who are at risk for osteoporosis. © RSNA, 2019 See also the editorial by Smith in this issue.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492986 | PMC |
http://dx.doi.org/10.1148/radiol.2019181648 | DOI Listing |
Int Immunopharmacol
December 2024
Department of Joint Surgery & Sports Medicine, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361004, China. Electronic address:
The role of extracellular vesicles (EVs) derived from inflammatory chondrocytes in EV-based therapy for osteoarthritis (OA) has received little attention. We examined the effects of EVs derived from both normal rat chondrocytes (nEVs) and IL-1β-treated rat chondrocytes (iEVs) on IL-1β-treated rat chondrocytes, macrophages, and osteoblasts, alongside mRNA-seq and miRNA-seq analyses of both them. Additionally, nEVs and iEVs were administered intra-articularly in the joints of rat models subjected to anterior cruciate ligament transection (ACLT), and the morphological alterations across the joints were assessed.
View Article and Find Full Text PDFBiochem Pharmacol
January 2025
The Second Affiliated Hospital, Guangzhou Medical University, China; Guangzhou Medical University, China. Electronic address:
Osteoporosis is characterized by excessive osteoclast activity leading to bone loss, decreased bone mineral density, and increased susceptibility to fractures. Through in vivo/vitro experiments, along with network pharmacology analysis, we aimed to explore the underlying mechanisms of Isoginkgetin (IGG) in inhibiting osteoclastogenesis, providing valuable insights for further research in the future. Firstly, we ascertained the safe concentration of IGG stimulation on BMMs, followed by a systematic exploration of the concentration gradient at which IGG inhibited osteoclastogenesis using TRAP analysis.
View Article and Find Full Text PDFSkeletal Radiol
November 2024
Department of Radiology, Seoul National University Bundang Hospital, 82 Gumi-Ro-173-Beon-Gil, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13620, Republic of Korea.
Objective: To determine an optimal region of interest (ROI) for opportunistic screening of osteoporosis in terms of short-term in vivo diagnostic precision.
Materials And Methods: We included patients who underwent two CT scans and one dual-energy X-ray absorptiometry scan within a month in 2022. Deep-learning software automatically measured the attenuation in L1 using 54 ROIs (three slice thicknesses × six shapes × three intravertebral levels).
Biochem Biophys Res Commun
December 2024
Institute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou 215006, China; Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address:
Exp Cell Res
January 2025
Department of Metabolism and Endocrinology, The Second Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi, China; Institute for the Study of Endocrinology and Metabolism in Jiangxi Province, Nanchang, 330006, China. Electronic address:
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!