The sensitivity of the blocking effect to outcome additivity pretraining has been used to argue that the phenomenon is the result of deductive inference, and to draw general conclusions about the nature of human causal learning. In two experiments, we manipulated participants' assumptions about the additivity of the outcome using pretraining before a typical blocking procedure. Ratings measuring causal judgments, confidence, and expected severity of the outcome were used concurrently to investigate how pretraining affected assumptions of outcome additivity and blocking. In Experiment 1, additive pretraining led to lower causal ratings and higher confidence ratings of the blocked cue, relative to control cues, consistent with the notion that additive pretraining encourages deductive reasoning. However, Experiments 1 and 2 showed that removing additivity assumptions through nonadditive pretraining had no impact on a statistically reliable blocking effect observed in a blocking procedure with no pretraining. We found no evidence that the blocking effect in the absence of pretraining was related to the participants' assumptions about the additivity of the outcome. Although additive pretraining may enhance blocking by encouraging deductive reasoning about the blocked cue, the evidence suggests that blocking in causal learning is not reliant on this reasoning and that humans do not readily engage in deduction merely because they possess the assumptions that permit its use.
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http://dx.doi.org/10.3758/s13421-019-00920-w | DOI Listing |
mSystems
January 2025
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
Unlabelled: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy in the oral-maxillofacial region with a poor prognosis. Oral microbiomes play a potential role in the pathogenesis of this disease. However, findings from individual studies have been inconsistent, and a comprehensive understanding of OSCC-associated microbiome dysbiosis remains elusive.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JH, United Kingdom.
The growing demand for biological products drives many efforts to maximize expression of heterologous proteins. Advances in high-throughput sequencing can produce data suitable for building sequence-to-expression models with machine learning. The most accurate models have been trained on one-hot encodings, a mechanism-agnostic representation of nucleotide sequences.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Thyroid & Breast Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.
Introduction: While most thyroid cancer patients have a favorable prognosis, anaplastic thyroid carcinoma (ATC) remains a particularly aggressive form with a median survival time of just five months. Conventional therapies offer limited benefits for this type of thyroid cancer. Our study aims to identify ATC patients who might bene t from immunotherapy.
View Article and Find Full Text PDFFront Public Health
January 2025
Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Background And Aim: Changes in cognitive function are commonly associated with aging in patients with cardiovascular diseases. The objective of this research was to construct and validate a nomogram-based predictive model for the identification of cognitive impairment in older people suffering from cardiovascular diseases.
Methods And Results: This retrospective study included 498 participants with cardiovascular diseases aged >60 selected from the NHANES 2011-2014.
Mult Scler
January 2025
Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
The past 25 years have brought extraordinary advances in our understanding of MS pathogenesis and the subsequent development of effective therapies. Collaborative genetics efforts have uncovered the association of 236 common DNA variants with disease susceptibility and the first association with disease severity, paving the way to more effective therapies, particularly for progressive forms of the disease. In parallel, and in addition to established environmental disease triggers or modifiers, new collaborative work has revealed new associations with components of the gut microbiome.
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