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An innovative complex-valued encoding black-winged kite algorithm for global optimization.
Sci Rep
January 2025
School of Electrical and Photoelectronic Engineering, West Anhui University, Lu'an, 237012, China.
The black-winged kite algorithm (BKA) constructed on the black-winged kites' migratory and predatory instincts is a revolutionary swarm intelligence method that integrates the Leader tactic with the Cauchy variation procedure to retrieve the expansive appropriate convergence solution. The essential BKA exhibits marginalized resolution efficiency, inferior assessment precision, and stagnant sensitive anticipation. To foster aggregate discovery intensity and advance widespread computational efficacy, an innovative complex-valued encoding BKA (CBKA) is presented to resolve the global optimization.
View Article and Find Full Text PDFEngineering covalent small molecule-RNA complexes in living cells.
Nat Chem Biol
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University of Innsbruck, Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), Innsbruck, Austria.
Covalent labeling of RNA in living cells poses many challenges. Here we describe a structure-guided approach to engineer covalent RNA aptamer-ligand complexes. The key is to modify the cognate ligand with an electrophilic handle that allows it to react with a guanine at the RNA binding site.
View Article and Find Full Text PDFPathophysiological effects of hypoxia on testis function and spermatogenesis.
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Discipline of Biological Sciences, College of Engineering, Science and Environment, The University of Newcastle, Callaghan, New South Wales, Australia.
Multiple conditions can cause hypoxia in the testis, including exposure to high altitude, sleep apnoea, testicular torsion and varicocele. Varicocele accounts for up to 44% of instances of primary infertility, but the cumulative contribution of hypoxic conditions to male infertility is undefined. Results of controlled hypobaric hypoxia studies have demonstrated a substantial detrimental effect of short-term and long-term exposures on sperm; however, downstream effects on embryo development and offspring health are less well understood.
View Article and Find Full Text PDFUnveiling the Dissociation Mechanism of Diglycine Perchlorate.
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High Pressure & Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, Trombay 400085, India.
Determining the dissociation mechanism of perchlorate materials remains a top priority to address sustainability, handling, processing, and synthesis issues of new and existing high-energy density materials vital to many industrial processes. We determined the dissociation mechanism of diglycine perchlorate (DGPCl) using vibrational spectroscopy, which unveiled the formation of ammonium perchlorate (AP) and carbon at high temperatures. Our studies establish that DGPCl shows multiple phase transitions upon heating.
View Article and Find Full Text PDFMonitoring the Land and Sea: Enhancing Efficiency Through CRISPR-Cas Driven Depletion and Enrichment of Environmental DNA.
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OceanOmics, The Minderoo Foundation, Perth, Australia.
Characterizing biodiversity using environmental DNA (eDNA) represents a paradigm shift in our capacity for biomonitoring complex environments, both aquatic and terrestrial. However, eDNA biomonitoring is limited by biases toward certain species and the low taxonomic resolution of current metabarcoding approaches. Shotgun metagenomics of eDNA enables the collection of whole ecosystem data by sequencing all molecules present, allowing characterization and identification.
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