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Base-Promoted Reactions of Fluoro- and Chloroarenes as a Route to -Aryl Indoles and Carbazoles. | LitMetric
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Base-Promoted Reactions of Fluoro- and Chloroarenes as a Route to -Aryl Indoles and Carbazoles.

Muhammad Asif Iqbal Hina Mehmood Jiaying Lv Ruimao Hua

Molecules

Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.

Published: March 2019

AI Article Synopsis

  • A new method for creating C-N bonds has been established using KOH and DMSO without the need for transition metals.
  • This process involves a reaction between chloroarenes or fluoroarenes and indoles or carbazole.
  • The result of this nucleophilic aromatic substitution is the successful formation of -arylated indoles and carbazoles.

Article Abstract

KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution () between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding -arylated indoles and carbazoles has been developed.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470585PMC
http://dx.doi.org/10.3390/molecules24061145DOI Listing

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