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Outcomes of upfront primary tumor resection in patients with synchronous wild-type metastatic colorectal cancer.
Am J Cancer Res
December 2024
Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung 80708, Taiwan.
This multicenter study explored the survival benefits of upfront primary tumor resection (PTR) followed by first-line cetuximab plus chemotherapy in real-world patients with wild-type metastatic colorectal cancer (mCRC). Treatment options for mCRC include chemotherapy, targeted therapy, immunotherapy, and surgery. The efficacy of upfront PTR in managing mCRC remains unclear.
View Article and Find Full Text PDFCombined chest wall perforator flap and synchronous fat grafting for partial breast reconstruction.
BMJ Case Rep
December 2024
Breast Surgery, Barts Health NHS Trust, London, UK.
Chest wall perforator flaps (CWPFs) have been a well-recognised surgical option for volume replacement following breast conservation surgery (BCS). However, the flap volume can sometimes be limited, which may adversely affect the aesthetic outcome or even disqualify the patient from having BCS. We report the first case of hybrid partial breast reconstruction using immediate autologous fat injection into CWPF.
View Article and Find Full Text PDFSynchronous gangrenous cholecystitis and appendicitis secondary to appendiceal diverticulum perforation.
J Surg Case Rep
December 2024
Northern Health Acute General Surgery Unit, 185 Cooper Street, Epping 3076, Australia.
Acute appendicitis and acute cholecystitis are among the commonest pathologies in acute general surgery. They are characterized by distinct symptoms, clinical examination findings and typical elements of the history which direct further investigations. In the absence of these classic findings, these diagnoses can be missed, particularly where they occur synchronously.
View Article and Find Full Text PDFUnexpected peritoneal metastases diagnosed at the time of primary colon cancer resection: controversies regarding options for management.
J Gastrointest Oncol
October 2024
Department of Colorectal Surgery, Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, USA.
Peritoneal metastases synchronously occurring in the patient with primary colon cancer causes that patient to be at high risk for subsequent disease progression within the abdomen and pelvis. If peritoneal metastases are preoperatively diagnosed, patients are likely to be treated with neoadjuvant chemotherapy with or without biological therapy prior to cytoreductive surgery (CRS). However, if one only considers patients with peritoneal metastases unexpectedly identified at the time of primary colon cancer resection, the optimal management strategy is neither standardized nor evidence based.
View Article and Find Full Text PDFCreating ionic current pathways: A non-implantation approach to achieving cortical electrical signals for brain-computer interface.
Biosens Bioelectron
January 2025
School of Biomedical Engineering, Tsinghua University, Beijing, 100084, China. Electronic address:
This study introduces a novel method for acquiring brain electrical signals comparable to intracranial recordings without the health risks associated with implanted electrodes. We developed a technique using ultrasonic tools to create micro-holes in the skull and insert hollow implants, preventing natural healing. This approach establishes an artificial ionic current path (AICP) using tissue fluid, facilitating signal transmission from the cortex to the scalp surface.
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