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Abnormalities in Blood Parameters in Athletes Taking Anabolic Androgenic Steroidal Agents; an Observational Clinical Study.
Subst Abuse Rehabil
January 2025
Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al Qura University, Makkah, Saudi Arabia.
Background: Many studies indicate that high and multiple doses of anabolic-androgenic steroids (AAS) for athletic enhancement can result in serious and irreversible adverse effects. A study that includes laboratory blood testing to evaluate the direct effects of AAS agents among users has not been previously undertaken. The purpose of this study was to investigate the adverse effects of the use of AAS by athletes and to determine whether AAS use leads to changes in certain blood parameters.
View Article and Find Full Text PDFGrowth Hormone Increase Induced by Oral Administration of Melatonin in a Young Woman With Sleep Disturbances.
JCEM Case Rep
February 2025
Clinica Medica 3, Department of Medicine-DIMED, University Hospital of Padova, Padova 35128, Italy.
Growth hormone (GH) secretion by the pituitary is regulated by stimulatory and inhibitory pathways such as growth hormone releasing hormone (GHRH) and somatostatin, respectively, being also modulated by different neurotransmitters acting at the hypothalamic/pituitary level. The pineal gland hormone melatonin regulates GH secretion in many mammals, including humans, although its role in modulating GH secretion has been debated. We describe the case of a young woman chronically taking melatonin for sleep disturbances, referring to her general practitioner for flushing that appeared just after starting melatonin intake.
View Article and Find Full Text PDFAnti-inflammatory effects of palm11-PrRP31 in a rat model of lipopolysaccharide-induced acute inflammation.
J Mol Endocrinol
January 2025
L Maletinska, Biochemistry, Czech Academy of Sciences, Praha, Czech Republic.
Lipopolysaccharides (LPS) are major components of Gram-negative bacteria. LPS not only induce endotoxemia and inflammation, but also contribute to various diseases. In experimental settings, LPS administration serves as a model for acute inflammatory responses.
View Article and Find Full Text PDFA Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance.
bioRxiv
January 2025
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Amylin analogs, including potential anti-obesity therapies like cagrilintide, act on neurons in the brainstem dorsal vagal complex (DVC) that express calcitonin receptors (CALCR). These receptors, often combined with receptor activity-modifying proteins (RAMPs), mediate the suppression of food intake and body weight. To understand the molecular and neural mechanisms of cagrilintide action, we used single-nucleus RNA sequencing to define 89 cell populations across the rat, mouse, and non-human primate caudal brainstem.
View Article and Find Full Text PDFHormonal and Glycemic Responses During and After Constant- and Alternating-Intensity Exercise.
J Clin Med
January 2025
Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias, 11527 Goudi, Greece.
Glucose metabolism and hormonal responses are largely affected by exercise intensity, which exhibits an alternating pattern in many sports activities. The aim of this study was to investigate and compare glycemic and hormonal responses during and after exercise of constant (CON) and alternating (ALT) intensity with the same duration and total work. Ten healthy male volunteers performed two, 60 min cycling exercise bouts in random order: the ALT bout, where exercise intensity alternated between 46.
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