The objective of this study was to evaluate the association of the human leukocyte antigen (HLA) class II genes , and with the humoral immune response elicited by inactivated Japanese encephalitis (JE) vaccine (IJEV). A total of 373 individuals aged 3-12 years in the Inner Mongolia Autonomous Region in China, who received two doses of IJEV at 0 and 7 days, were enrolled in the current study. Based on the individuals' specific JE virus (JEV)-neutralizing antibodies (NAbs), they were divided into a seropositive and a seronegative group. , and were genotyped using a sequencing-based typing method. Next, the association of the HLA class II genes and their haplotypes with antibody response was evaluated. Based on NAbs, a total of 161 individuals were classified as seropositive and 212 as seronegative. was significantly associated with JEV seropositivity ( < 0.001, OR = 0.364, 95% CI: 0.221-0.600), while was significantly associated with JEV seronegativity ( = 5.03 × 10, OR = 7.341, 95% CI: 2.876-18.736). The haplotypes , and were very frequent in the seropositive group, while , and were very frequent in the seronegative group. The presence of , and was associated with a higher geometric mean titer (GMT) of NAbs than that of at the locus ( < 0.05). At the locus, the presence of was associated with higher GMTs than that of and ( < 0.05), and the presence of and was associated with higher GMTs than that of ( < 0.05). The present study suggests that HLA class II genes may influence the antibody response to IJEV.
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| http://dx.doi.org/10.3389/fimmu.2019.00428 | DOI Listing |
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