Objective: To evaluate the association of ESR1 rs2234693 and rs9340799 polymorphisms with radiographic defined knee osteoarthritis (OA), a case-control and meta-analysis was performed.
Methods: A total of 25 case-control studies with 7,144 cases and 8,468 controls with were included.
Results: There was a significant association between rs2234693 polymorphism and radiographic knee OA under heterozygote model (CT vs. TT: OR = 1.164, 95% CI 1.053-1.286, p = 0.003). However, there was no association between rs9340799 and radiographic knee OA. In subgroup analysis by ethnicity, risk estimates were not augmented.
Conclusions: Our results showed that the ESR1 rs2234693 polymorphism might be associated with radiographic defined knee OA, but not rs9340799.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411600 | PMC |
| http://dx.doi.org/10.1016/j.jor.2019.02.022 | DOI Listing |
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