Biochim Biophys Acta Biomembr
Dept. of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794-5215, United States of America. Electronic address:
Published: June 2019
Sterol structure influences liquid ordered domains in membranes, and the dependence of biological functions on sterol structure can help identify processes dependent on ordered domains. In this study we compared the effect of sterol structure on ordered domain formation in symmetric vesicles composed of mixtures of sphingomyelin, 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and cholesterol, and in asymmetric vesicles in which sphingomyelin was introduced into the outer leaflet of vesicles composed of DOPC and cholesterol. In most cases, sterol behavior was similar in symmetric and asymmetric vesicles, with ordered domains most strongly stabilized by 7-dehydrocholesterol (7DHC) and cholesterol, stabilized to a moderate degree by lanosterol, epicholesterol and desmosterol, and very little if at all by 4-cholesten-3-one. However, in asymmetric vesicles desmosterol stabilized ordered domain almost as well as cholesterol, and to a much greater degree than epicholesterol, so that the ability to support ordered domains decreased in the order 7-DHC > cholesterol > desmosterol > lanosterol > epicholesterol > 4-cholesten-3-one. This contrasts with values for intermediate stabilizing sterols in symmetric vesicles in which the ranking was cholesterol > lanosterol ~ desmosterol ~ epicholesterol or prior studies in which the ranking was cholesterol ~ epicholesterol > lanosterol ~ desmosterol. The reasons for these differences are discussed. Based on these results, we re-evaluated our prior studies in cells and conclude that endocytosis levels and bacterial uptake are even more closely correlated with the ability of sterols to form ordered domains than previously thought, and do not necessarily require that a sterol have a 3β-OH group.
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http://dx.doi.org/10.1016/j.bbamem.2019.03.012 | DOI Listing |
BMC Psychol
January 2025
School of Management, Jinan University, No.601, Huangpu Avenue West, Guangzhou, Guangdong Province, 510632, China.
Different from previous studies on the motives of compensatory consumption, this review focuses on the strategies of compensatory consumption. This literature review aims to introduce two main strategies for compensatory consumption, within-domain and across-domain compensation. Within-domain compensation is a consumption strategy to repair a self-discrepancy in a specific domain, while across-domain compensation refers to a consumption strategy that consumers restore their global self-worth by affirming themselves in other important domains yet unrelated to the self-discrepancies.
View Article and Find Full Text PDFSci Bull (Beijing)
January 2025
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing 100871, China. Electronic address:
Z-classified topological phases lead to a larger-than-unity number of topological states. However, these multiple topological states are only localized at the corners in nonlocal systems. Here, first, we rigorously prove that the multiple topological states of nonlocal Su-Schrieffer-Heeger (SSH) chains can be inherited and realized by local aperiodic chains with only the nearest couplings.
View Article and Find Full Text PDFPsychiatry Res Neuroimaging
January 2025
Departamento de Morfologia e Genética, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP, Brazil. Electronic address:
Alcohol use disorder (AUD) is a multifactorial disease closely related to neurodevelopment and environmental factors that influence behavior. This study explored the relationships between brain volume and behavior from an Exploratory Structural Equation Modeling (ESEM) based on the Research Domain Criteria. High-resolution magnetic resonance imaging scans were acquired from recent patients with AUD (n = 50) and healthy controls (HC=50).
View Article and Find Full Text PDFMed Care
January 2025
John Ware Research Group (JWRG), Watertown, MA.
Background: Comprehensive health-related quality of life (QOL) assessment under severe respondent burden constraints requires improved single-item scales for frequently surveyed domains. This article documents how new single-item-per-domain (SIPD) QOL General (QGEN-8) measures were constructed for domains common to SF-36 and results from the first psychometric tests comparing scores for the new measure in relation to those for the SF-36 profile and summary components.
Research Design: Online NORC surveys of adults, ages 19-93 (mean=52 y) representing the US population in 2020 (N=1648) included QGEN-8 and SF-36 items measuring physical (PF), social (SF), role physical (RP) and role emotional (RE) functioning and feelings of bodily pain (BP), vitality (VT), and mental health (MH).
Plant Biotechnol J
January 2025
Institute of Plant Biotechnology and Cell Biology, Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
The production of complex multimeric secretory immunoglobulins (SIgA) in Nicotiana benthamiana leaves is challenging, with significant reductions in complete protein assembly and consequently yield, being the most important difficulties. Expanding the physical dimensions of the ER to mimic professional antibody-secreting cells can help to increase yields and promote protein folding and assembly. Here, we expanded the ER in N.
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