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Conformational Flexibility of D1-Glu189: A Crucial Determinant in Substrate Water Selection, Positioning, and Stabilization within the Oxygen-Evolving Complex of Photosystem II.
ACS Omega
December 2024
Center for Quantum Information and Quantum Biology, Osaka University, Toyonaka, Osaka 560-0043, Japan.
Photosynthetic water oxidation is a vital process responsible for producing dioxygen and supplying the energy necessary to sustain life on Earth. This fundamental reaction is catalyzed by the oxygen-evolving complex (OEC) of photosystem II, which houses the MnCaO cluster as its catalytic core. In this study, we specifically focus on the D1-Glu189 amino acid residue, which serves as a direct ligand to the MnCaO cluster.
View Article and Find Full Text PDFBrain-inspired multisensory integration neural network for cross-modal recognition through spatiotemporal dynamics and deep learning.
Cogn Neurodyn
December 2024
School of Electrical and Information Engineering, Tianjin University, Tianjin, 300072 China.
The integration and interaction of cross-modal senses in brain neural networks can facilitate high-level cognitive functionalities. In this work, we proposed a bioinspired multisensory integration neural network (MINN) that integrates visual and audio senses for recognizing multimodal information across different sensory modalities. This deep learning-based model incorporates a cascading framework of parallel convolutional neural networks (CNNs) for extracting intrinsic features from visual and audio inputs, and a recurrent neural network (RNN) for multimodal information integration and interaction.
View Article and Find Full Text PDFEvolving Food Allergy Clinical Trials to Become More Patient-Centered.
J Allergy Clin Immunol Pract
December 2024
Section of Allergy and Immunology, Children's Hospital Colorado, Department of Pediatrics, University of Colorado School of Medicine. Electronic address:
The current FDA paradigm may not fully capture important patient-centered outcomes or measure a primary outcome that is truly meaningful to patients. Patient reported outcome measures (PROMs) are standardized tools measuring the patient's experience in food allergy clinical trials, which can help support shared decision-making (SDM) and further our understanding of treatment impact. Food allergy PROMs include quality of life (QoL), health state utility (HSU), severity, and self-efficacy measures.
View Article and Find Full Text PDFRevisiting marine heatwaves baselines in warming oceans under nonstationary condition.
Sci Total Environ
December 2024
Department of Natural Resources, Isfahan University of Technology, Isfahan, Iran.
Marine Heatwaves (MHWs) are prolonged episodes of above- 'normal' Sea Surface Temperature (SST) which have imposed detrimental impacts on oceans and their dependent ecosystem services. The key question still remained unresolved or at least still not fully addressed in MHW science, is 'What is a valid normal or baseline?'. In other words, can the conventional 'normal' serve as a realistic valid baseline in today's oceans experiencing the impacts of contemporaneous climatic changes and global warming during anthropogenic era? To robustly address this issue, we attempted to propose a methodology for identifying MHW thresholds that accounts for SST warming.
View Article and Find Full Text PDFEmbracing the complexity of lived experiences in psychiatry research: Reflexivity, cultural sensitivity, and emergent design.
World J Psychiatry
December 2024
School of Education, University Teknologi Malaysia, Johor Bahru 81310, Johor, Malaysia.
This article examines the critical integration of reflexivity, cultural sensitivity, and emergent design in qualitative psychiatry research focused on lived experiences. While quantitative methods offer essential clinical insights, qualitative approaches provide a deeper understanding of the emotional, psychological, and social dimensions of mental health. Reflexivity enables researchers to remain aware of how their personal biases and professional backgrounds shape data interpretation.
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