Background: Multiple sclerosis (MS) and psoriasis vulgaris (PV) are two disorders with autoimmune pathophysiology and a supposed altered T helper (T) cell response.
Objective: To report a case of concomitant relapsing remitting MS and PV treated with different immunomodulatory medications, particularly secukinumab and rituximab.
Methods: Case report.
Results: In a 68-year-old woman diagnosed with MS and PV, secukinumab alleviated the dermatological condition, but could not control neuroinflammation. Rituximab treatment halted MS activity, but led to a flare-up of dermatological inflammation.
Conclusion: The presented case suggests that the pathomechanisms of MS and PV differ regarding involvement of T and B cells with implications for therapeutic approaches.
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| http://dx.doi.org/10.1016/j.msard.2019.03.009 | DOI Listing |
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