AI Article Synopsis
- The study compares two chemotherapy regimens for early-stage breast cancer: a longer regimen of four cycles of FEC followed by four cycles of docetaxel (4FEC-4T) and a shorter regimen of three cycles of FEC followed by three cycles of docetaxel (3FEC-3T).
- The analysis involved 137 patients in the 4FEC-4T group matched with 411 patients in the 3FEC-3T group, focusing on event-free survival (EFS) and distant disease-free survival (DDFS) as primary and secondary endpoints.
- Results showed that the longer regimen (4FEC-4T) led to significantly improved EFS and DDFS compared to
Article Abstract
Benefit of longer course of taxane-anthracycline-based adjuvant chemotherapy is yet to be identified. We conducted a retrospectively matched-pair analysis to compare four cycles of fluorouracil, epirubicin and cyclophosphamide followed by four cycles of docetaxel (4FEC-4T) with three cycles of FEC followed by three cycles of docetaxel (3FEC-3T) as adjuvant chemotherapy for early-stage breast cancer. One hundred and thirty-seven patients treated with 4FEC-4T were matched to 411 in 3FEC-3T. The primary end point was event-free survival (EFS). The secondary end point was distant disease-free survival (DDFS). The 4FEC-4T resulted in significantly longer EFS than matched 3FEC-3T (p = 0.020). Furthermore, DDFS was superior in the 4FEC-4T to that in the 3FEC-3T (p = 0.046). Extending taxane-anthracycline-based regimens with identical schedules significantly improves EFS and DDFS for early-stage breast cancer.
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| http://dx.doi.org/10.2217/fon-2018-0666 | DOI Listing |
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