AI Article Synopsis
- Circular RNAs are a type of non-coding RNA that lack traditional terminal structures and play significant roles in regulating linear mRNAs and various diseases, particularly cancers.
- Recent findings highlight their involvement in the development, progression, and treatment responses of head and neck cancers, which have low survival rates despite being common worldwide.
- The study reviews the biological characteristics of circular RNAs, their impact on head and neck cancer pathology, potential as diagnostic/prognostic tools, and suggests avenues for future research in this area.
Article Abstract
Circular RNAs are abundant endogenous non-coding RNA with no 5' cap and 3' polyadenylation tail that modify liner mRNAs and have no terminal structures. Our knowledge of the biogenesis of circular RNAs has been expanded, and circular RNAs were shown to be key regulators of various diseases, especially cancers. Head and neck cancers are the sixth most popular cancers worldwide, and the overall survival rates remain unsatisfactory. Recent studies have indicated that circular RNAs are involved in the tumorigenesis, progression, invasion and chemosensitivity of head and neck cancers and that some circular RNAs could serve as diagnostic and prognostic biomarkers. In this study, we summarize research advances in the regulation of circular RNA biogenesis, their characteristics and functions, the involvement of circular RNAs in the pathophysiology of head and neck cancers and their potential clinical utilization, as well as the likely directions of future studies.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427840 | PMC |
| http://dx.doi.org/10.1186/s12943-019-1003-5 | DOI Listing |
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