Palladium-catalyzed allylation of aminophenol with alkynes to construct C-N bonds.

Org Biomol Chem

College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014, China.

Published: April 2019

A method for the allylic alkylation of aminophenol with alkynes was developed using a palladium-catalysed allylation reaction with 100% atom economy. A series of structurally diverse N-allylic substituted allylamines were synthesized in good yields with high chemo-, regio-, and stereoselectivities under mild conditions.

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Source
http://dx.doi.org/10.1039/c9ob00333aDOI Listing

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