AI Article Synopsis
- Researchers isolated one new and one known alkamide compound from a specific extract, as well as four known compounds from another extract using chromatographic techniques.
- Characterization of these compounds was done with NMR and MS spectroscopic methods.
- The new alkamide exhibited moderate cytotoxicity against leukemia cell lines, showing greater activity than the standard drug doxorubicin against drug-resistant cells, suggesting the potential for future testing on various drug-resistant human cells.
Article Abstract
In our continuous search for cytotoxic compounds from the genus chromatographic separation of the MeOH/CHCl (1:1) extract of yielded one new alkamide; 4-(isoprenyloxy)-3-methoxy-3,4-deoxymethylenedioxyfagaramide () and a known one; fagaramide (). Similarly, from the MeOH/CHCl (1:1) extract of the stem bark of four known compounds; canthin-6-one (), dihydrochelerythrine (), lupeol () and sesamin () were isolated. Characterization of the structures of these compounds was achieved using spectroscopic techniques (NMR and MS). Using resazurin reduction assay , and displayed moderate cytotoxicity with IC values below 50 μM against the drug sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cell lines. It is interesting to note that was more active than the standard drug, doxorubicin against CEM/ADR5000 leukemia cells. Compounds and showed good selectivity on leukemia cells than normal cells. In future studies should be tested against a panel of drug resistant human cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2019.1587424 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!