Tears of the anterior cruciate ligament (ACL) are common among young athletes and diagnosis may be difficult especially in the young population. Therefore, finding a new method to increase the correct diagnosis is necessary. This double-blind prospective observational study was conducted on 51 patients with suspected ACL rupture. In this study, in addition to the standard protocols, the oblique-sagittal and oblique-coronal MRI were assessed and used in three different methods, including A method (orthogonal MRI protocol), B method (orthogonal MRI protocol and oblique-sagittal MRI), and C method (orthogonal MRI protocol and oblique-coronal MRI). In detecting both complete and partial rupture of ACL, B method had highest diagnostic accuracy (kappa = 0.338, P=0.001), and after that, C method had acceptable accuracy (kappa = 0.292, P=0.011). In addition, in detecting a partial rupture of ACL, B method (kappa = 0.5, P<0.001), and C method had acceptable accuracy (kappa = 0.361, P=0.006). Meanwhile, in detecting a complete rupture of ACL, B method had the highest diagnostic accuracy (kappa = 0.898, P<0.001), and subsequently A method had significant accuracy (kappa = 0.812, P<0.001). Our results showed that the evaluation of ACL rupture by oblique-sagittal MRI in addition to orthogonal MRI protocol is accurate and with high sensitivity and specificity values. It allows to find abnormal images immediately with higher accuracy in the emergency department and more critically ill patients may benefit from the advantages of this imaging protocol.
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http://dx.doi.org/10.25122/jml-2018-0015 | DOI Listing |
Nucleic Acids Res
January 2025
Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Achieving targeted hypermutation of specific genomic sequences without affecting other regions remains a key challenge in continuous evolution. To address this, we evolved a T7 RNA polymerase (RNAP) mutant that synthesizes single-stranded DNA (ssDNA) instead of RNA in vivo, while still exclusively recognizing the T7 promoter. By increasing the error rate of the T7 RNAP mutant, it generates mutated ssDNA that recombines with homologous sequences in the genome, leading to targeted genomic hypermutation.
View Article and Find Full Text PDFNanoscale
January 2025
Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr. 47, Moscow 119991, Russia.
Adapting biological systems for nanoparticle synthesis opens an orthogonal Green direction in nanoscience by reducing the reliance on harsh chemicals and energy-intensive procedures. This study addresses the challenge of efficient catalyst preparation for organic synthesis, focusing on the rapid formation of palladium (Pd) nanoparticles using bacterial cells as a renewable and eco-friendly support. The preparation of catalytically active nanoparticles on the bacterium VKM B-3302 represents a more suitable approach to increase the reaction efficiency due to its resistance to metal salts.
View Article and Find Full Text PDFHeliyon
January 2025
Faculty of Material and Manufacturing Technologies, Malek Ashtar University of Technology, P.O. Box 1774-15875, Tehran, Iran.
The potential of epoxy-graphene oxide (GO) nanocomposites to improve the mechanical characteristics of conventional epoxy resins is causing them to gain prominence. This makes them appropriate for advanced engineering applications, including structural materials, automotive, and aerospace. This study aimed to develop an epoxy/GO composite with improved mechanical properties through synthesizing epoxy/GO samples with varying GO content (from 0.
View Article and Find Full Text PDFInt J Dent
January 2025
Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Investigating the pattern of extension in the periapical (PA) inflammatory lesions is important in the treatment plan and prognosis of treatment. This study evaluated the topography of PA inflammatory lesions in the first molars using cone-beam computed tomography (CBCT). In this descriptive study, 197 CBCT images about patients in the age group of 14-77 years were analyzed.
View Article and Find Full Text PDFFront Oncol
January 2025
Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Purpose: This study aimed to provide quantitative information for implementing Lattice radiotherapy (LRT) using a medical linear accelerator equipped with the Millennium 120 multi-leaf collimator (MLC). The research systematically evaluated the impact of varying vertex diameters and separations on dose distribution, peak-to-valley dose ratio (PVDR), and normal tissue dose.
Methods: A cylindrical Virtual Water™ phantom was used to create LRT treatments using the Eclipse version 16.
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