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Concurrent Eruptive Melanocytic Nevi and Multiple Keratoacanthomas Induced by Encorafenib.
Cureus
September 2024
Oncology, Biokliniki Athinon, Athens, GRC.
Article Synopsis
- - A case study discusses a 64-year-old male with metastatic colorectal cancer who developed severe itching and new skin lesions after treatment with encorafenib and panitumumab, medications targeting cancer pathways.
- - The patient showed a mix of skin lesions, including benign moles and keratoacanthomas, with further evaluation confirming a link between the skin reactions and the use of encorafenib, as validated by the Naranjo scale.
- - Stopping the medications led to significant improvement in skin lesions, highlighting the importance of ongoing skin assessments for patients on BRAF inhibitors to manage side effects effectively.
MULTIPLE KERATINOCYTIC CANCERS AFTER INTAKE OF ANTIHYPERTENSIVES (LISINOPRIL/BISOPROLOL/HCT) AND ANTIARRHYTMICS (PROPAFENONE): THE IMPORTANT NEW LINKS TO THE NITROSO-CONTAMINATION AND THE METABOLIC REPROGRAMMING OF THE FUTURE CANCER CELL.
Georgian Med News
June 2024
3Department of Dermatology and Venereology, Military Medical Academy, Sofia, Bulgaria.
Article Synopsis
- The mechanisms behind the development of skin tumors are still not fully understood, particularly regarding the roles of photosensitivity and phototoxicity.
- Recent studies have linked specific nitrosamines, contaminants in common pharmaceuticals, to gene and phototoxicity in humans, raising concerns about their potential carcinogenic effects.
- Long-term use of contaminated medications may contribute to skin cancer risk by interfering with tumor suppressor genes and activating oncogenes, affecting overall cancer development.
Keratoacanthoma centrifugum marginatum: An unusual case.
Photodiagnosis Photodyn Ther
December 2021
Dermatology Hospital of Southern Medical University, No. 2 Lujing Road, Yuexiu District, Guangzhou City, Guangdong Province, China. Electronic address:
Keratoacanthoma centrifugum marginatum (KCM) of the skin is a rare variant of cutaneous keratoacantoma. KCM was first reported in 1962 andpresents with progressive peripheral expansion , no spontaneous clearing and a bank-shaped outer wall with concurrent central healing. Treatment options include topical and systemic therapies.
View Article and Find Full Text PDFIneffectiveness of radiotherapy for the treatment of keratoacanthoma centrifugum marginatum: A case report.
Dermatol Ther
July 2019
Department of Dermatology, Hitachi General Hospital, Hitachi, Japan.
Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacantoma (KA). Although KCM shares histological and clinical features with KA, KCM has no tendency of spontaneous regression, and presents with progressive peripheral expansion with a bank-shaped outer wall and concurrent central healing. As such, early diagnosis and proper treatment of the patient are required.
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