Tritrichomonas foetus is a parasite that has been definitively identified as an agent of trichomonosis, a disease characterized by chronic diarrhea. T. foetus colonizes portions of the feline large intestine, and manifests as chronic and recurrent diarrhea with mucus and fresh blood, which is often unresponsive to common drugs. Diagnosis of a trichomonad infection is made by either the demonstration of the trophozoite on a direct fecal smear, fecal culture and subsequent microscopic examination of the parasite, or extraction of DNA in feces and amplification by the use of molecular tools. T. foetus is commonly misidentified as other flagellate protozoa such as Giardia duodenalis and Pentatrichomonas hominis. Without proper treatment, the diarrhea may resolve spontaneously in months to years, but cats can remain carriers of the parasite. This paper intends to serve as a source of information for investigators and veterinarians, reviewing the most important aspects of feline trichomonosis, such as trichomonad history, biology, clinical manifestations, pathogenesis, world distribution, risk factors, diagnosis, and treatment.
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View Article and Find Full Text PDFArticle Synopsis
- The study aimed to check for the presence of Tritrichomonas foetus in male reproductive tissues of bulls that tested positive and analyzed how post mortem tissue acidity affects testing accuracy.
- Eight bulls were euthanized, and samples from their testicles, epididymis, and accessory sex glands were collected; however, T foetus was not found in any of these tissues.
- Researchers found that as the pH of the penis and prepuce decreased after death, the cycle threshold values increased, indicating that pH changes could influence the effectiveness of detecting genetic material over time.
Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis.
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October 2024
Department of Medicine, University of California San Diego, La Jolla, California, United States of America.
Article Synopsis
- Trichomonas vaginalis causes trichomoniasis, a widespread STD that affects over a hundred million people, and resistance to common treatments like metronidazole is increasing.
- The study explored using Tritrichomonas foetus, a related parasite, as a better animal model for testing new treatments since it caused reliable infections in mice, unlike T. vaginalis.
- Findings showed that while some drugs had similar effectiveness on both parasites, proteasome inhibitors were less effective on T. foetus, suggesting the need for targeted drug development and further understanding of genetic differences between the two organisms.
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