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Utilizing the AJCC 8 Staging to Discriminate Survival Outcomes in HPV-associated Oropharyngeal Squamous Cell Carcinoma.
Anticancer Res
April 2024
Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea;
Background/aim: The American Joint Committee on Cancer (AJCC) staging 8th edition introduced major changes in the TNM staging of oropharyngeal squamous cell carcinoma (OPSCC) based on the human papillomavirus (HPV) status. This study aimed to observe how well the AJCC staging 8 edition precisely discriminates survival outcomes in patients with HPV-associated OPSCC using a large population database.
Materials And Methods: Using the Surveillance, Epidemiology, and End Results database between 2010 and 2016, 7,448 patients with HPV-associated OPSCC were enrolled.
Reconsidering the absence of extrapancreatic extension in T staging for pancreatic adenocarcinoma in the AJCC (8 ed) Staging Manual using the National Cancer Database.
J Gastrointest Surg
November 2023
Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Chongno-gu, Seoul, 03080, South Korea.
Purpose: Although the concept of extrapancreatic extension (EPEx) was removed in the eighth edition of the American Joint Committee on Cancer pancreatic cancer staging system, several studies have supported the prognostic significance of EPEx. This study aimed to investigate the significance of EPEx in pancreatic ductal adenocarcinoma (PDAC) using the National Cancer Database (NCDB).
Methods: Data of patients who underwent resection for PDAC between 2006 and 2016 were extracted and analyzed from the NCDB.
The 8th Edition TNM Stage Reclassification of T4 Non-Small Cell Lung Cancer: A Granular Examination of Short and Long-Term Outcomes.
Clin Lung Cancer
September 2023
Department of Thoracic Surgery, Montreal General Hospital, McGill University, Montreal, Quebec, Canada. Electronic address:
Article Synopsis
- The study compares outcomes for non-small-cell lung cancer (NSCLC) patients classified as pT4 by the AJCC7 and AJCC8 criteria, highlighting differences in tumor size and characteristics.
- It found that patients categorized under AJCC7 had worse perioperative outcomes, such as higher 90-day mortality rates, and were more likely to have lymph node involvement and metastasis.
- Despite these differences, long-term survival rates were similar, indicating the complexity of the AJCC8 classification and suggesting a need for ongoing adjustments in future cancer classifications.
Comparison of the Seventh and Eighth Edition of American Joint Committee on Cancer (AJCC) Staging for Selected and Nonselected Oropharyngeal Squamous Cell Carcinomas.
Oncologist
February 2022
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Objectives: The eighth edition American Joint Committee on Cancer (AJCC) Staging incorporates significant changes to the seventh edition in the staging of oropharyngeal squamous cell carcinomas (OPSCC). An important change was the inclusion of OPSCC associated with the human papilloma virus (HPV). Our goal is to compare the performance of both staging systems for patients with HPV-selected and unselected clinical characteristics for OPSCC.
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