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A Novel Homozygous Frameshift Variant in Causes Spondyloocular Syndrome in a Consanguineous Pakistani Family. | LitMetric

AI Article Synopsis

Article Abstract

We report on three new patients with spondyloocular syndrome (SOS) in a consanguineous Pakistani family. All three patients present progressive generalized osteoporosis, short stature, recurrent fractures, hearing loss and visual impairments. WES revealed a novel homozygous frameshift variant in exon 11 of (NG 012175.1, NP_071450.2) resulting in loss of evolutionary conserved amino acid sequences (840 - 865/865) at C-terminus p.R840fs115. Sanger Sequencing confirmed the presence of the novel homozygous mutation in all three patients while the parents were heterozygous carriers of the mutation, in accordance with an autosomal recessive inheritance pattern. Only nine variants worldwide have previously been reported in in patients with SOS phenotype. These three patients with novel homozygous variant extend the genotypic and phenotypic spectrum of SOS.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411848PMC
http://dx.doi.org/10.3389/fgene.2019.00144DOI Listing

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