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Life stage impact on the human skin ecosystem: lipids and the microbial community.
NPJ Biofilms Microbiomes
January 2025
A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS), Singapore, Republic of Singapore.
Article Synopsis
- The study examines the relationship between skin oxylipins, which are bioactive lipids produced from fatty acids by skin microbes, and different microbial communities on the skin of children and adults.
- Findings highlighted that Malassezia restricta, a type of skin fungus, has a positive impact on the production of a specific oxylipin (9,10-DiHOME) in adults, while showing a negative correlation with its precursor in children, indicating differences in skin chemistry across age groups.
- The research suggests a complex communication system between skin microbes and host lipid metabolism that could have implications for skin health, emphasizing the need for further exploration of these interactions for potential therapeutic applications.
Different fungal signatures in ALD and MAFLD.
Front Microbiol
November 2024
Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Objective: This study investigates the differential impact of fecal fungal microbiota on the pathogenesis of alcohol-associated liver disease (ALD) and metabolic-associated fatty liver disease (MAFLD). We aim to delineate distinct microbial patterns across various stages of each disease.
Methods: We conducted fungal internal transcribed spacer 2 (ITS2) sequencing analysis on fecal samples from 48 ALD patients, 55 MAFLD patients, and 64 healthy controls (HCs).
Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease.
Microbiol Spectr
January 2025
Department of Laboratory Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, China.
The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared the gut fungal communities of 214 ACVD patients with those of 171 healthy controls using shotgun metagenomic sequencing and examined their interactions with gut bacterial communities and network key taxa. The gut mycobiome composition in ACVD patients is significantly different, showing a rise in opportunistic pathogens like , , and , with and showing the most significant changes (Wilcoxon rank-sum test, < 0.
View Article and Find Full Text PDFAffinity of Malassezia and Other Yeasts for Pulmonary Lipids.
Mycopathologia
December 2024
Medical Mycology Laboratory, Department of Plant Production and Microbiology, Institute for Healthcare and Biomedical Research of Alicante (ISABIAL), University Miguel Hernández, Campus of San Juan de Alicante, 03550, Alicante, Spain.
Pulmonary surfactant, the primary substance lining the epithelium of the human Lower Respiratory Tract (LRT), is rich in lipids, with dipalmitoyl-phosphatidylcholine (DPPC) being the most abundant. Although surfactants are known to have antifungal activity against some yeast species, the significant presence of species like Malassezia restricta in the lung mycobiome suggests that these yeasts may exhibit some level of lipo-tolerance or even lipo-affinity for pulmonary lipids. This study explored the affinity and tolerance of yeasts, identified as significant members of the lung microbiome, to pulmonary lipids through culture-based methods.
View Article and Find Full Text PDFSpeciation of Malassezia and determination of sebum and hydration levels in secondary school students in Nigeria.
Arch Dermatol Res
December 2024
Department of Medicine and Surgery, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Article Synopsis
- Pityriasis versicolor (PV) is a skin condition linked to Malassezia species, and this study focused on its relationship with sebum and hydration levels in adolescents in Ibadan, Nigeria.
- Higher sebum levels and lower skin hydration were observed in students with PV compared to those without.
- Malassezia globosa was identified as the most common species associated with PV, but no strong connections were found between the species and clinical features, indicating a need for further research.
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