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Targeting Tumor Endothelial Cells by EGCG Using Specific Liposome Delivery System Inhibits Vascular Inflammation and Thrombosis.
Cancer Med
December 2024
Vascular Biology and Molecular Pathology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.
Background: Inflammation is one of the hallmarks of cancer and is associated with tumor growth. Tumor endothelial cells (TECs) demonstrate inflamed phenotypes. Endothelial inflammation initiates thrombus formation, which is the second cause of cancer-related deaths.
View Article and Find Full Text PDFEvidence for Aldosterone Antagonism in Heart Failure.
Card Fail Rev
November 2024
Department of Cardiology, King George's Medical University Uttar Pradesh, India.
Article Synopsis
- Activation of the renin-angiotensin-aldosterone system is crucial in heart failure, where excess aldosterone causes various cardiovascular issues like vascular stiffness and inflammation.
- Aldosterone antagonists, such as spironolactone and eplerenone, have shown significant benefits in improving cardiovascular outcomes in heart failure studies like RALES, EPHESUS, and EMPHASIS-HF.
- Ongoing research is exploring newer-generation mineralocorticoid antagonists and aldosterone synthase inhibitors, particularly their effects on patients with heart failure and preserved ejection fraction.
Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report.
Arterioscler Thromb Vasc Biol
January 2025
Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden (M.M.O., A.N., M.D., H.S., T.M., K.G.).
Background: Cerebral cavernous malformation (CCM) is a disease characterized by vascular malformations that primarily develop in the brain. These malformations are prone to leak, and their rupture or thrombotic closure can cause life-threatening hemorrhages and strokes. Mouse models have been instrumental to study the disease, but most cause premature lethality, precluding the investigation of disease mechanisms through intravital microscopy.
View Article and Find Full Text PDFFungal Necrotizing Fasciitis Due to Mucormycosis Following Contaminated Substance Inoculation: A Report of Two Cases.
Eur J Case Rep Intern Med
October 2024
Dermatology, Centro de Referência Nacional em Dermatologia Sanitária Dona Libânia, Fortaleza, Brazil.
Unlabelled: Mucormycosis is a life-threatening fungal infection caused by Mucorales fungi, characterized by angioinvasion and tissue necrosis. While it predominantly affects immunocompromised individuals, it can also occur in immunocompetent patients through traumatic inoculations, such as contaminated surgical dressings or injections. We report two cases of cutaneous mucormycosis following the shared use of contaminated intramuscular corticosteroid injections (dexamethasone).
View Article and Find Full Text PDFCancer is not a guest.
Transl Oncol
January 2025
Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
In a recent article titled "Embracing Cancer Complexity: Hallmarks of Systemic Disease" published in Cell, Swaton et al. propose the idea of cancer as a guest that develops within a host. They discuss the possible causes and events of neoplastic cell dysregulations within an organism, highlighting events such as cachexia and thrombosis.
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