New asterosaponin, acanthaglycoside G (), along with three previously known steroidal oligoglycosides (), were isolated from the ethanolic extract of the starfish , collected off the coast of Vietnam. The structure of was mainly elucidated by extensive NMR and ESIMS techniques as sodium 6--{-D-fucopyranosyl-(1→2)--D-quinovopyranosyl-(1→4)-[-D-quinovopyranosyl-(1→2)]--D-quinovopyranosyl-(1→3)--D-quinovopyranosyl}-6-hydroxy-5-pregn-9(11)-en-20-one-3-yl sulfate. Compounds and showed slight cytotoxic activities against cancer RPMI-7951, HT-29, and MDA-MB-231 cell lines, but effectively inhibited in non-toxic concentrations colony formation of HT-29 and MDA-MB-231 cells and cell migration of MDA-MB-231 cells. Compounds and were inactive or less active, respectively.
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