AI Article Synopsis

  • The study investigates autoantibody prevalence, cytokine levels, and B-cell subset distribution in women with hyperprolactinemia (HPRL).
  • Results show that a higher percentage of women with HPRL had autoantibodies compared to healthy women, along with significantly elevated levels of interleukin-4 (IL-4) and interleukin-6 (IL-6).
  • Additionally, women with HPRL exhibited more naive IgD-IgM B cells and antibody-secreting B cells, suggesting a link between high prolactin levels and autoimmune responses.

Article Abstract

Purpose: Hyperprolactinemia (HPRL) has been reported in many autoimmune diseases. However, the serum autoantibody profile and peripheral B-cell subset distribution in women with HPRL are largely unknown. The current study aimed to investigate the autoantibody prevalence and cytokine levels as well as to further explore the B-cell subset distribution in women with HPRL.

Methods: Sera from 202 women with HPRL and 97 healthy women were included in this study. All sera were examined for prolactin (PRL), anti-nuclear antibody (ANA), rheumatoid factor, anticardiolipin (ACL), immunoglobulin G, immunoglobulin M, complement 3, complement 4, interleukin 4 (IL-4) and interleukin 6 (IL-6). Peripheral blood was collected from 22 women with HPRL and 19 healthy women, and B-cell subsets were measured by flow cytometry.

Results: At least one autoantibody was found in 47 out of 202 women with HPRL compared with 9 of 97 healthy women (p < 0.001). The levels of IL-4 (p < 0.0001) and IL-6 (p < 0.0001) were significantly higher in women with HPRL than in healthy women. The percentages of naive IgDIgM B cells (B cells, p < 0.0001), antibody-secreting cells (p = 0.007) and unswitched memory B cells (p = 0.004) among the total B cells from HPRL women were significantly higher than those from healthy women.

Conclusions: Women with HPRL had a higher prevalence of autoantibodies, higher serum levels of IL-4 and IL-6, and more B cells, antibody-secreting B cells and unswitched memory B cells than healthy women. These data imply that a high level of PRL is associated with autoimmune diseases.

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Source
http://dx.doi.org/10.1007/s12020-019-01896-yDOI Listing

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