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| http://dx.doi.org/10.1038/s41419-019-1501-9 | DOI Listing |
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Modified (2'-deoxy)adenosines activate autophagy primarily through AMPK/ULK1-dependent pathway.
Bioorg Med Chem Lett
November 2024
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; RUDN University, 117198 Moscow, Russia. Electronic address:
Article Synopsis
- * Scientists think that by activating autophagy, we can help treat diseases like cancer, obesity, and neurodegenerative diseases.
- * A study tested some new compounds to see if they could activate autophagy better than a common drug called AICAr, and found some that worked well even without needing a specific protein called AMPK.
Cafestol inhibits colon cancer cell proliferation and tumor growth in xenograft mice by activating LKB1/AMPK/ULK1-dependent autophagy.
J Nutr Biochem
July 2024
Key Laboratory of Nutrition and Food Safety of Yunnan Provincial Education Department, Kunming Medical University, Kunming, China; Yunnan Provincial Key Laboratory of Public Health and Biosafety & School of Public Health, Kunming Medical University, Kunming, China; Baoshan College of Traditional Chinese Medicine, Baoshan, China. Electronic address:
Chemotherapy failure in colorectal cancer patients is the major cause of recurrence and poor prognosis. As a result, there is an urgent need to develop drugs that have a good chemotherapy effect while also being extremely safe. In this study, we found cafestol inhibited colon cancer growth and HCT116 proliferation in vivo and in vitro, and improved the composition of intestinal flora.
View Article and Find Full Text PDFRigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells.
Cancer Lett
November 2023
Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, China; Zhejiang Provincial Clinical Research Center for CANCER, China; Cancer Center of Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address:
Rigosertib (RGS) is a benzyl styryl sulfone which exhibits impressive cytotoxicity in cancer cells. However, its modulating effect on tumor immune microenvironment remains elusive. In our experiments, compared with immunodeficient mouse model, increased tumor growth arrest and robust anti-tumor immunity were observed in RGS-treated colorectal cancer (CRC) isograft tumors in immunocompetent mice.
View Article and Find Full Text PDFMetrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy.
J Adv Res
September 2023
Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing 210009, China; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600 Singapore, Singapore. Electronic address:
Article Synopsis
- - Metrnl is a hormone linked to benefits in obesity, inflammation, and heart health, but its specific role in diabetic cardiomyopathy (DCM) was previously unclear.
- - This study reveals that lower levels of Metrnl in diabetic mice worsen heart issues, while increasing Metrnl protects against cardiac damage and dysfunction.
- - Metrnl works by activating the autophagy pathway and inhibiting harmful cellular signaling, suggesting it could be a promising target for DCM treatment.
Tangeretin Protects Mice from Alcohol-Induced Fatty Liver by Activating Mitophagy through the AMPK-ULK1 Pathway.
J Agric Food Chem
September 2022
Key Laboratory of the Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing 211166, China.
Alcoholic beverages are widely consumed all over the world, but continuous ethanol exposure leads to hepatic steatosis that, without proper treatment, will later develop into severe liver disorders. In this study, we investigated the potential protective effect of tangeretin, a flavonoid derived from citrus peel, against alcoholic fatty liver. The effects of tangeretin were analyzed by oral intake in a chronic-binge alcohol feeding C57BL/6j mouse model, while the underlying mechanism was explored by studies performed on ethanol-treated hepatic AML-12 cells.
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