AI Article Synopsis
- GROWTH-REGULATING FACTORs (GRFs) are transcription factors essential for regulating plant growth and development through their interaction with a cofactor, GRF-INTERACTING FACTOR (GIF).
- The GRF-GIF complex requires the SWITCH2/SUCROSE NONFERMENTING2 chromatin remodeling complex to function properly, particularly in ensuring the growth potential of certain cells during organ formation.
- Recent studies have further clarified the roles of the GRF-GIF-miR396 module and its evolution, offering new insights beyond what was previously understood in this field.
Article Abstract
GROWTH-REGULATING FACTORs (GRFs) are sequencepecific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requires the SWITCH2/ SUCROSE NONFERMENTING2 chromatin remodeling complex. One of the most conspicuous roles of the duo is conferring the meristematic potential on the proliferative and formative cells during organogenesis. GRF expression is post-transcriptionally down-regulated by microRNA396 (miR396), thus constructing the GRF-GIF-miR396 module and fine-tuning the duo's action. Since the last comprehensive review articles were published over three years ago, many studies have added further insight into its action and elucidated new biological roles. The current review highlights recent advances in our understanding of how the GRF-GIF-miR396 module regulates plant growth and development. In addition, I revise the previous view on the evolutionary origin of the GRF gene family. [BMB Reports 2019; 52(4): 227-238].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507847 | PMC |
| http://dx.doi.org/10.5483/BMBRep.2019.52.4.051 | DOI Listing |
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