AI Article Synopsis
- Langerhans cell histiocytosis is a rare disease mostly affecting children and young adults, with an estimated incidence of 0.2-0.5 per 100,000 in children.
- An 8-year-old Moroccan girl presented with painful swelling in both forearms, and although initial imaging was inconclusive, a biopsy confirmed Langerhans cell histiocytosis.
- The case is notable due to the unusual bilateral lesions, and the condition should be considered in the differential diagnosis for osteomyelitis and Ewing's sarcoma.
Article Abstract
Background: Langerhans cell histiocytosis previously known as histiocytosis X is a rare disease of children and young adults with a very broad clinical spectrum. In children, its annual incidence is estimated between 0.2-0.5 per 100,000.
Case Representation: An 8-year-old Moroccan girl with no known personal or family history presented to our institution with painful swelling of both forearms. An X-ray and magnetic resonance imaging were inconclusive. We then performed a biopsy curettage (of her left forearm). Microscopic analysis followed by immunohistochemical analysis disclosed a diagnosis of Langerhans cell histiocytosis. No chemotherapy was necessary. Clinical and radiological improvement was achieved after 6 months.
Conclusion: The particularity of this observation is the bilaterality of the lesion on both forearms and it has not previously been reported. Langerhans cell histiocytosis should be included in the differential diagnosis of osteomyelitis and Ewing's sarcoma.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423802 | PMC |
| http://dx.doi.org/10.1186/s13256-019-2011-1 | DOI Listing |
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