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Isolation and characterization of numerous novel phages targeting diverse strains of the ubiquitous and opportunistic pathogen Achromobacter xylosoxidans.
PLoS One
September 2014
Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures, Department of Microbial Ecology and Diversity Research, Braunschweig, Germany.
The clinical relevance of nosocomially acquired infections caused by multi-resistant Achromobacter strains is rapidly increasing. Here, a diverse set of 61 Achromobacter xylosoxidans strains was characterized by MultiLocus Sequence Typing and Phenotype MicroArray technology. The strains were further analyzed in regard to their susceptibility to 35 antibiotics and to 34 different and newly isolated bacteriophages from the environment.
View Article and Find Full Text PDFPotency of IMP-10 metallo-beta-lactamase in hydrolysing various antipseudomonal beta-lactams.
J Med Microbiol
August 2008
Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo 142-8555, Japan.
Limited beta-lactams show antipseudomonal activity. The rapid spread of IMP-type metallo-beta-lactamases (MBLs), which have a broad spectrum of substrates and a poor susceptibility to clinically available inhibitors, further restricts beta-lactam use. In the present study, we evaluated the potency of IMP-10 MBL in hydrolysing antipseudomonal beta-lactams currently available in the clinic.
View Article and Find Full Text PDFAntibiotic susceptibility of preoperative normal conjunctival bacteria.
Am J Ophthalmol
April 2005
Department of Ophthalmology, School of Medicine, Stanford University, Stanford, California 94305, USA.
Purpose: To determine the antibiotic susceptibility of preoperative conjunctival bacterial flora.
Design: In vitro study.
Methods: Antibiotic susceptibility of conjunctival bacterial strains isolated from 164 patients undergoing intraocular surgery was determined using the Kirby-Bauer disk-diffusion technique.
Serotypes and anti-microbial susceptibility of Plesiomonas shigelloides isolates from humans, animals and aquatic environments in different countries.
Comp Immunol Microbiol Infect Dis
March 2004
Department of Veterinary Microbiology, Section of Bacteriology, SLU, Box 7036, S-750 07, Uppsala, Sweden.
Article Synopsis
- A study examined 73 strains of Plesiomonas shigelloides from humans, animals, and aquatic environments for their serotypes and antibiotic resistance.
- A high percentage of strains were typeable (86.3% by O and 94.5% by H serotyping), with 57 different serotypes identified, notably O11:H2 and O23:H1a1b found in Finland, Cuba, and Europe.
- Most strains showed high susceptibility to tested antimicrobials, but 92-96% were resistant to broad-spectrum penicillins, with no link found between resistance patterns and serotypes.
Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.
Antimicrob Agents Chemother
July 1999
Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, 53100-Siena, Italy.
Production of a metallo-beta-lactamase activity was detected in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate (isolate VR-143/97) from an Italian inpatient at the Verona University Hospital (northern Italy). The metallo-beta-lactamase determinant was isolated from a genomic library of VR-143/97, constructed in an Escherichia coli plasmid vector, by screening for clones with reduced susceptibility to imipenem. Sequencing of the cloned gene revealed that it encoded a new class B beta-lactamase that was named VIM-1.
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