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hijacks the tumor microenvironment in liver cancer cells in a multifaceted approach: A falling row of dominoes.
World J Gastroenterol
December 2024
Department of Gastroenterology, University of Balamand, Beirut 3187, Beyrouth, Lebanon.
(. ) is widely used in traditional Chinese medicine due to its anti-tumor effects. .
View Article and Find Full Text PDFWhen pulmonary arterial hypertension and pregnancy meet: a multidisciplinary clinical experts review.
Arch Gynecol Obstet
December 2024
Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Corso Strada Nuova, 65, 27100, Pavia, Italy.
Pulmonary hypertension (PH) is a rare condition characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance, potentially leading to right ventricular failure. Pulmonary arterial hypertension (PAH) is the most common type of PH in women of childbearing age and, as per the modified World Health Organization (mWHO) classification of maternal cardiovascular risk, it falls into mWHO class IV and pregnancy is contraindicated. These patients face an exceptionally high risk of maternal mortality and morbidity, with estimated maternal cardiac event rates ranging from 40 to 100% during pregnancy, because physiological changes happening in pregnancy exacerbate the disorder.
View Article and Find Full Text PDFThe "Domino effect" in MASLD: The inflammatory cascade of steatohepatitis.
Eur J Immunol
April 2024
Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly common complication of obesity, affecting over a quarter of the global adult population. A key event in the pathophysiology of MASLD is the development of metabolic-associated steatohepatitis (MASH), which greatly increases the chances of developing cirrhosis and hepatocellular carcinoma. The underlying cause of MASH is multifactorial, but accumulating evidence indicates that the inflammatory process in the hepatic microenvironment typically follows a pattern that can be roughly divided into three stages: (1) Detection of hepatocyte stress by tissue-resident immune cells including γδ T cells and CD4CD8 double-negative T cells, followed by their secretion of pro-inflammatory mediators, most notably IL-17A.
View Article and Find Full Text PDFTrickle-down effects of temporal leadership: The roles of leadership perspective and identification with leader.
Front Psychol
September 2022
College of Business, Shanghai University of Finance and Economics, Shanghai, China.
Based on social learning theory and the trickle-down effects, in which behavioral patterns cascade from one management level to the next (also known as the falling domino effect), we attempt to answer whether upper-level managers' temporal leadership can be transferred to lower-level managers to form their temporal leadership, and what the mediating mechanisms and boundary conditions for this occurrence are. By analyzing the data from 234 middle-level managers and 686 junior managers/employees, we found that top managers' temporal leadership was positively associated with middle-level managers' temporal leadership through the mediating role of middle-level managers' temporal leadership perspective and that the relationship was moderated by middle-level managers' identification with the top manager. Identification with the top manager, in particular, strengthens both the top manager's positive effect on middle-level managers' temporal leadership and the top manager's temporal leadership's mediating role in this relationship through their temporal leadership perspective.
View Article and Find Full Text PDFBone mineral density, limb muscle mass, muscle strength, and exercise capacity are reduced in female patients with distal radius fractures when the unaffected side grip strength is less than 18 kg.
J Orthop Sci
November 2023
Department of Orthopedics, Okayama University Medical School, Japan.
Background: Prevention of domino effects after distal radius fractures is important for improving life expectancy. Fragility fractures secondary to falls are associated with decreased bone mineral density, muscle strength, and exercise capacity. Grip strength is one of the simplest and most useful tests to comprehensively judge muscle strength.
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