AI Article Synopsis
- Nutritional studies face challenges due to the lack of suitable models, as conventional cell lines and animal models do not accurately reflect human responses.
- Enteroids, derived from intestinal stem cells, are advanced models that replicate key features of human intestinal epithelium and can be cultured long-term without losing their characteristics.
- This review emphasizes the significance of enteroids for studying various aspects of nutrition and intestinal function, suggesting they could improve research in this field.
Article Abstract
Nutritional studies are greatly hampered by a paucity of proper models. Previous studies on nutrition have employed conventional cell lines and animal models to gain a better understanding of the field. These models lack certain correlations with human physiological responses, which impede their applications in this field. Enteroids are cultured from intestinal stem cells and include enterocytes, enteroendocrine cells, goblet cells, Paneth cells, and stem cells, which mimic hallmarks of in vivo epithelium and support long-term culture without genetic or physiological changes. Enteroids have been used as models to study the effects of diet and nutrients on intestinal growth and development, ion and nutrient transport, secretory and absorption functions, the intestinal barrier, and location-specific functions of the intestine. In this review, the existing models for nutritional studies are discussed and the importance of enteroids as a new model for nutritional studies is highlighted. Taken together, it is suggested that enteroids can serve as a potential model system to be exploited in nutritional studies.
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| http://dx.doi.org/10.1002/mnfr.201801143 | DOI Listing |
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