Similar Publications

Rational design of N-glycosyltransferases from Aggregatibacter aphrophilus to synthesize Gal-modified glycoconjugates targeting hepatocellular carcinoma cells.

Int J Biol Macromol

December 2024

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China. Electronic address:

Hepatocellular carcinoma (HCC) significantly impacts human health due to its tendency to develop multi-drug resistance. Regarding the treatment of HCC, galactosylated conjugates can target drug delivery. Bacterial N-glycosyltransferases (NGTs) catalyze glucosylation or galactosylation of the Asn residue motif Asn-X-Ser/Thr (X ≠ P).

View Article and Find Full Text PDF

Protocol for analyzing the function of the type VI secretion system of the oral symbiont Aggregatibacter aphrophilus in targeting pathobionts.

STAR Protoc

December 2024

Division of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Alfred Nobels Allé 8, 14104 Huddinge, Stockholm, Sweden. Electronic address:

Article Synopsis
  • The protocol outlines a method for assessing the fitness of the oral symbiont A. aphrophilus related to its type VI secretion system (T6SS) using competition assays and metaproteomics.
  • It includes guidelines for designing T6SS-specific mutants and conducting competition tests with the pathobiont A. actinomycetemcomitans in biofilm models.
  • The biofilm model simulates the oral plaque ecosystem, featuring seven species, and for detailed procedures, it refers to the work of Oscarsson et al.
View Article and Find Full Text PDF

A rare case of infantile acute polymicrobial dacryocystitis due to Serratia marcescens, Haemophilus aphrophilus, and Prevotellaintermedia.

J AAPOS

December 2024

McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas; Department of Ophthalmology and Visual Science, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas. Electronic address:

Infantile acute dacryocystitis is an acute inflammation of the lacrimal sac in infants. The most common pathogens are Gram-positive cocci and Gram-negative rods. We report a case of infantile polymicrobial acute dacryocystitis.

View Article and Find Full Text PDF

Epidural Abscess Caused by Aggregatibacter Aphrophilus.

Isr Med Assoc J

October 2024

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel, Reichman University, Herzliya, Israel.

View Article and Find Full Text PDF
Article Synopsis
  • - The study explores the role of different bacteria in chronic airway disease (CAD), focusing on how they might influence inflammation in the lungs, particularly looking for anti-inflammatory species.
  • - Using microbiome samples and inflammatory data from patients with CAD, researchers found that the genus Aggregatibacter was more common in patients with lower inflammation levels, linked to reduced inflammatory markers IL-8 and IL-1β.
  • - Laboratory tests indicate that Aggregatibacter species have the potential to reduce inflammation in lung cells without harming their viability, suggesting a possible therapeutic role for these bacteria in managing CAD symptoms.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!